Mannich Reaction of Acetophenone, Aromatic Aldehydes and Aro-matic Amines Catalyzed by Tungstophosphoric Acid in Water

Chin. J. Org. Chem. ›› 2011, Vol. 31 ›› Issue (10): 1714-1718. Previous Articles Next Articles

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水相中磷钨酸催化苯乙酮、芳香醛和芳香胺的Mannich反应

陈君丽，解正峰*，邢烨

(新疆大学化学与化工学院石油天然气精细化工教育部重点实验室乌鲁木齐 830046)

收稿日期:2010-11-05 修回日期:2011-04-11 发布日期:2011-05-30
通讯作者: 解正峰 E-mail:xiezhf72@yahoo.com.cn

Mannich Reaction of Acetophenone, Aromatic Aldehydes and Aro-matic Amines Catalyzed by Tungstophosphoric Acid in Water

CHEN Jun-Li, JIE Zheng-Feng, XING Ye

(Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046)

Received:2010-11-05 Revised:2011-04-11 Published:2011-05-30
Contact: Zheng-Feng Xie E-mail:xiezhf72@yahoo.com.cn

Mannich reaction of acetophenone, aromatic aldehydes and aromatic amines catalyzed by tungstophosphoric acid in water afforded the corresponding β-amino ketone derivatives in high yields at room temperature. The reaction catalyzed by tungstophoshporic acid has advantage of mild reaction conditions, simple workup procedures and easy isolation.

Key words: tungstophosphoric acid, Mannich reaction, β-amino ketone derivatives, water, catalyzsis

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CHEN Jun-Li, JIE Zheng-Feng, XING Ye. Mannich Reaction of Acetophenone, Aromatic Aldehydes and Aro-matic Amines Catalyzed by Tungstophosphoric Acid in Water[J]. Chin. J. Org. Chem., 2011, 31(10): 1714-1718.

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水相中磷钨酸催化苯乙酮、芳香醛和芳香胺的Mannich反应

Mannich Reaction of Acetophenone, Aromatic Aldehydes and Aro-matic Amines Catalyzed by Tungstophosphoric Acid in Water

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