Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities

doi:10.6023/cjoc1106032

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (02): 349-353 .DOI: 10.6023/cjoc1106032 Previous Articles Next Articles

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新型烟酰胺腺嘌呤二核苷酸(NAD)类似物的合成及其辅酶活性

侯淑华^a,b, 刘武军^a, 赵宗保^a

a 中国科学院大连化学物理研究所生物技术部大连 116023;
b 中国科学院研究生院北京 100049

收稿日期:2011-06-03 修回日期:2011-09-22 发布日期:2012-03-09
通讯作者: 赵宗保 E-mail:zhaozb@dicp.ac.cn

Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities

Hou Shuhua^a,b, Liu Wujun^a, Zhao Zongbao^a

a Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023;
b Graduate University of Chinese Academy of Sciences, Beijing 100049

Received:2011-06-03 Revised:2011-09-22 Published:2012-03-09

Four methods were tested to synthesize nicotinamide adenine dinucleotide (NAD) analogs, and 5 NAD analogs were prepared. Assays of these NAD analogs indicated that malic enzyme and alcohol dehydrogenase had about 13%～30% enzymatic activity in the presence of analog 3b or 3d, whereas significantly lower activities were observed in the presence of analog 3a, 3c or 3e.

Key words: NAD analog, pyrophosphate, bioactivity, alcohol dehydrogenase

Cite this article

Hou Shuhua, Liu Wujun, Zhao Zongbao. Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities[J]. Chin. J. Org. Chem., 2012, 32(02): 349-353 .

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新型烟酰胺腺嘌呤二核苷酸(NAD)类似物的合成及其辅酶活性

Synthesis of Novel Nicotinamide Adenine Dinucleotide (NAD) Analogs and Their Coenzyme Activities

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