One-Pot Synthesis of 4(3H)-Quinazolinone under Base Condition

doi:10.6023/cjoc1108102

Chin. J. Org. Chem. ›› 2012, Vol. ›› Issue (03): 532-537.DOI: 10.6023/cjoc1108102 Previous Articles Next Articles

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碱性条件下4(3H)-喹唑啉酮的一锅合成

刘长娥^a, 于琪瑶^b, 唐健红^a,c, 李加荣^a

a 北京理工大学化工与环境学院北京 100081;
b 北京理工大学化学学院北京100081;
c 华侨大学化工学院厦门 362021

收稿日期:2011-08-10 修回日期:2011-11-21 发布日期:2012-03-24
通讯作者: 李加荣 E-mail:jrli@bit.edu.cn

One-Pot Synthesis of 4(3H)-Quinazolinone under Base Condition

Liu Change^a, Yu Qiyao^b, Tang Jianhong^a,c, Li Jiarong ^a

a School of Chemical Engineering and Environment, Beijing Institude of Technology, Beijjing 100081;
b School of Chemistry, Beijing Institude of Technology, Beijjing 100081;
c College of Chemical Engineering, Huaqiao University, Xiamen 362021

Received:2011-08-10 Revised:2011-11-21 Published:2012-03-24

A series of 4(3H)-quinazolinones 3 were obtained from the one-pot synthesis of available substituted aromatic o-aminonitriles 1 with aldehydes 2 in the present of base. This tandem transformation was included in addition, intramolecular Pinner reaction, Dimroth rearrangement and oxidative dehydrogenation. The structures of products were characterized by ¹H NMR, ¹³C NMR, IR spectra and elemental analysis.

Key words: one-pot synthesis, aromatic o-aminonitrile, aldehyde, base catalysis, 4(3H)-quinazolinone

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Liu Change, Yu Qiyao, Tang Jianhong, Li Jiarong . One-Pot Synthesis of 4(3H)-Quinazolinone under Base Condition[J]. Chin. J. Org. Chem., 2012, (03): 532-537.

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碱性条件下4(3H)-喹唑啉酮的一锅合成

One-Pot Synthesis of 4(3H)-Quinazolinone under Base Condition

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