A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions

doi:10.6023/cjoc1108072

Chin. J. Org. Chem. ›› 2012, Vol. ›› Issue (03): 612-615.DOI: 10.6023/cjoc1108072 Previous Articles Next Articles

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无溶剂条件下简单、有效地合成1,6-二氢嘧啶-6-酮衍生物

刘丽华^a, 殷姗^b, 夏盛^b, 蔡佩君^a, 荣良策^a,b

a 中国矿业大学化工学院徐州 221008;
b 徐州师范大学化学化工学院徐州 221116

收稿日期:2011-08-07 修回日期:2011-10-22 发布日期:2012-03-24
通讯作者: 蔡佩君, 荣良策 E-mail:lcrong@xznu.edu.cn; lcrong2005@yahoo.com
基金资助:
江苏省高校自然科学基础研究基金(No. 08KJB150017)及徐州师范大学科研平台(No. 10XLS02)资助项目.

A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions

Liu Lihua^a, Yin Shan^b, Xia Sheng^b, Cai Peijun^a, Rong Liangce^a,b

a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
b College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116

Received:2011-08-07 Revised:2011-10-22 Published:2012-03-24
Supported by:
Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017) and the Research Platform Foundation of Xuzhou Normal University (No. 10XLS02).

An efficient and facile synthesis of 2-amino-1,6-dihydro-6-oxo-pyrimidine derivatives via reaction of aromatic aldehydes, ethyl 2-cyanoacetate and guanidine carbonate by using NaOH and K₂CO₃ as catalyst under solvent-free conditions at about 70 ℃ is reported. This protocol has the advantages of shorter time, mild conditions, easy work-up and environmental friendliness. The products were identified by IR, ¹H NMR and HRMS techniques, and that of 4e was additionally confirmed by X-ray diffraction analysis.

Key words: 6-oxo-pyrimidine, heterocyclic compound, solvent-free reaction

Cite this article

Liu Lihua, Yin Shan, Xia Sheng, Cai Peijun, Rong Liangce. A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions[J]. Chin. J. Org. Chem., 2012, (03): 612-615.

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无溶剂条件下简单、有效地合成1,6-二氢嘧啶-6-酮衍生物

A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions

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