Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (4): 1527-1542.DOI: 10.6023/cjoc202007034 Previous Articles     Next Articles



贾丰成a,*(), 罗娜a, 徐程b,*(), 吴安心c   

  1. a 武汉工程大学化学与环境工程学院 武汉 430205
    b 湖北师范大学化学化工学院 黄石 435002
    c 华中师范大学化学学院 武汉 430079
  • 收稿日期:2020-07-12 修回日期:2020-10-01 发布日期:2020-10-28
  • 通讯作者: 贾丰成, 徐程
  • 基金资助:
    国家自然科学基金(21901193); 湖北省自然科学基金(2018CFB149); 湖北省教育厅科学研究计划中青年人才(Q20181509); 武汉工程大学科学研究基金(K201834)

Recent Advances in the Synthesis of Benzoheterocyclic Compounds Involving Isatins

Fengcheng Jiaa,*(), Na Luoa, Cheng Xub,*(), Anxin Wuc   

  1. a School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073
    b Hubei Collaborative Innovation Center for Rare Metal Chemistry, Hubei Key Laboratory of Pollutant Analysis and Reuse Technology, Hubei Normal University, Huangshi 435002
    c Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079
  • Received:2020-07-12 Revised:2020-10-01 Published:2020-10-28
  • Contact: Fengcheng Jia, Cheng Xu
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    National Natural Science Foundation of China(21901193); Natural Science Foundation of Hubei Province(2018CFB149); Young and Middle-Aged Talent Program of Hubei Provincial Department of Education(Q20181509); Science Foundation of Wuhan Institute of Technology(K201834)

Isatin is a natural small molecule compound of the indole class. Due to its unique structure, low cost and easy availability, the use of isatin as a starting material to construct complex and diverse heterocyclic compounds has been a research hotspot in the field of organic synthesis. Since isatin possess rich reaction sites, it has a significant step advantage in converting it into similar heterocycles. In recent years, the great progress has been made in the construction of heterocyclic compounds based on domino reactions involving isatins. According to the different types of heterocycles, the research progress in the synthesis of benzoheterocyclic compounds by the domino reactions related to isatins is briefly discussed.

Key words: isatins, domino reactions, benzoheterocyclic compounds, reaction mechanism