One-Pot Synthesis of 5-Aryl Diketo-1H-tetrazol Using 1-Methyl-1-methoxyethyl as Protective Group

doi:10.6023/cjoc1112111

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (08): 1543-1546.DOI: 10.6023/cjoc1112111 Previous Articles Next Articles

Notes

以1-甲基-1-甲氧基乙基为保护基的一锅法合成5-芳香二酮-1H-四氮唑

刘明明, 钟东威, 周家毅, 周璐, 叶德泳

复旦大学药学院药物化学教研室上海 201203

收稿日期:2011-12-11 修回日期:2012-03-06 发布日期:2012-04-11
通讯作者: 叶德泳 E-mail:dyye@shmu.edu.cn
基金资助:
国家自然科学基金(Nos. 20902013, 30973641)资助项目.

One-Pot Synthesis of 5-Aryl Diketo-1H-tetrazol Using 1-Methyl-1-methoxyethyl as Protective Group

Liu Mingming, Zhong Dongwei, Zhou Jiayi, Zhou Lu, Ye Deyong

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203

Received:2011-12-11 Revised:2012-03-06 Published:2012-04-11
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 20902013, 30973641).

One-pot reaction was reported for the synthesis of 5-aryl diketo-1H-tetrazols (2). Meanwhile, 1-methyl-1- methoxyethyl (MME) as protective group of tetrazole was firstly reported. The protective and deprotective reactions were performed in moderate conditions and the new method leads to simplified process and increased productivity. Six novel 5-aryl diketo-1H-tetrazol compounds were synthesized by using this method for further biological screening.

Key words: 5-aryl diketo-1H-tetrazol, 1-methyl-1-methoxyethyl (MME), tetrazole protection, one-pot synthesis

Cite this article

Liu Mingming, Zhong Dongwei, Zhou Jiayi, Zhou Lu, Ye Deyong. One-Pot Synthesis of 5-Aryl Diketo-1H-tetrazol Using 1-Methyl-1-methoxyethyl as Protective Group[J]. Chin. J. Org. Chem., 2012, 32(08): 1543-1546.

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以1-甲基-1-甲氧基乙基为保护基的一锅法合成5-芳香二酮-1H-四氮唑

One-Pot Synthesis of 5-Aryl Diketo-1H-tetrazol Using 1-Methyl-1-methoxyethyl as Protective Group

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