One-Pot Synthesis and Biological Activity of 2-Acetamide-thiazole Derivatives under Microwave Irradiation

doi:10.6023/cjoc1201302

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (9): 1746-1748.DOI: 10.6023/cjoc1201302 Previous Articles Next Articles

Notes

微波辐射下 2-乙酰氨基噻唑衍生物的一锅法合成及生物活性研究

袁明月^a, 刘敏^a, 张英群^a, 闫红飞^b, 李德富^a, 张冬暖^a, 刘卉闵^a

a 河北农业大学理学院保定 071001;
b 河北农业大学植物保护学院保定 071001

收稿日期:2012-01-30 修回日期:2012-05-18 发布日期:2012-04-24
通讯作者: 张英群 E-mail:yingqun0203@163.com
基金资助:
河北省教育厅计划(No.2009435)和河北农业大学非生命学科和新兴学科基金(No.2009020)资助项目

One-Pot Synthesis and Biological Activity of 2-Acetamide-thiazole Derivatives under Microwave Irradiation

Yuan Mingyue^a, Liu Min^a, Zhang Yingqun^a, Yan Hongfei^b, Li Defu^a, Zhang Dongnuan^a, Liu Huimin^a

a College of Science, Agricultural University of Hebei, Baoding 071001;
b College of Plant Protection, Agricultural University of Hebei, Baoding 071001

Received:2012-01-30 Revised:2012-05-18 Published:2012-04-24
Supported by:
Project supported by the Foundation of Hebei Educational Committee (No.2009435) and the Non-life Disciplines and Emerging Disciplines Foundation of Hebei Agricultural University (No.2009020)

An efficient one-pot method is used to prepare a series of 2-acetamide-thiazole derivatives from α-bromoketone, thiourea and acetic anhydride under microwave irradiation. The reaction procedures have the advantages of easy work up, short time and simple operation. The products were identified by ¹H NMR and IR spectra and elemental analysis. These compounds exhibit good antimicrobial activities.

Key words: microwave irradiation, one-pot synthesis, 2-acetamide-thiazole derivatives, biological activity

Cite this article

Yuan Mingyue, Liu Min, Zhang Yingqun, Yan Hongfei, Li Defu, Zhang Dongnuan, Liu Huimin. One-Pot Synthesis and Biological Activity of 2-Acetamide-thiazole Derivatives under Microwave Irradiation[J]. Chin. J. Org. Chem., 2012, 32(9): 1746-1748.

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微波辐射下 2-乙酰氨基噻唑衍生物的一锅法合成及生物活性研究

One-Pot Synthesis and Biological Activity of 2-Acetamide-thiazole Derivatives under Microwave Irradiation

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