Synthesis of 1-(2-Amino-3,5-dicyano-4-aryl-4H-pyran-6-yl)guaiazulenes

doi:10.6023/cjoc1201102

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (9): 1741-1745.DOI: 10.6023/cjoc1201102 Previous Articles Next Articles

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1-(2-氨基-3,5-二氰基-4-芳基-4H-吡喃-6-基)愈创兰烃薁的合成

王道林, 李帝, 曹亮

辽宁省功能化合物合成与应用重点实验室渤海大学化学化工与食品安全学院锦州 121003

收稿日期:2012-01-06 修回日期:2012-05-18 发布日期:2012-03-01
通讯作者: 王道林 E-mail:wangdaolin@sina.com.cn
基金资助:
辽宁省科技厅(No.2011220022)资助项目

Synthesis of 1-(2-Amino-3,5-dicyano-4-aryl-4H-pyran-6-yl)guaiazulenes

Wang Daolin, Li Di, Cao Liang

Key Laboratory of Synthesis & Application of Functional Compound, College of Chemistry, Chemical Engineering & Food Safety, Bohai University, Jinzhou 121003

Received:2012-01-06 Revised:2012-05-18 Published:2012-03-01
Supported by:
Project supported by the Science and Technology Department of Liaoning Province (No.2011220022)

An efficient and convenient method for the one-pot three-component synthesis of 1-(2-amino-3,5-dicyano-4-aryl-4H-pyran-6-yl)guaiazulene derivatives by the condensation of 1-cyanoacetylguaiazulene, aldehydes, and malononitrile in the presence of ammonium acetate has been described. The structures of synthesized compounds were determined by NMR, IR, MS techniques and elemental analysis. This method provides several advantages such as good yield and simple work-up procedure.

Key words: azulene, 1-cyanoacetylguaiazulene, 4H-pyran, ammonium acetate, synthesis

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Wang Daolin, Li Di, Cao Liang. Synthesis of 1-(2-Amino-3,5-dicyano-4-aryl-4H-pyran-6-yl)guaiazulenes[J]. Chin. J. Org. Chem., 2012, 32(9): 1741-1745.

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1-(2-氨基-3,5-二氰基-4-芳基-4H-吡喃-6-基)愈创兰烃薁的合成

Synthesis of 1-(2-Amino-3,5-dicyano-4-aryl-4H-pyran-6-yl)guaiazulenes

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