A Facile and Efficient Synthesis of 2-Amino-6-methyl-4-aryltetrahydronaphthalene Derivatives

doi:10.6023/cjoc201210014

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (03): 648-651.DOI: 10.6023/cjoc201210014 Previous Articles Next Articles

Notes

方便、有效地合成2-氨基-4-芳基-6-甲基四氢化萘衍生物

荣良策^a,b, 魏贤勇^a, 宗志敏^a, 韩笑^b, 张诚义^b, 沈小沣^b, 陈翔^b

a 中国矿业大学化工学院徐州 221008;
b 江苏师范大学化学化工学院徐州 221116

收稿日期:2012-10-12 修回日期:2012-11-21 发布日期:2012-11-26
通讯作者: 荣良策, 魏贤勇 E-mail:lcrong@jsnu.edu.cn or lcrong2005@yahoo.com; wei_xianyong@163.com
基金资助:
江苏省高校自然科学基础研究基金(No. 08KJB150017)、江苏师范大学科研平台(No. 10XLS02)和国家自然科学基金委员会创新研究群体科学基金 (No. 50921002)资助项目.

A Facile and Efficient Synthesis of 2-Amino-6-methyl-4-aryltetrahydronaphthalene Derivatives

Rong Liangce^a,b, Wei Xianyong^a, Zong Zhimin^a, Han Xiao^b, Zhang Chengyi^b, Shen Xiaofeng^b, Chen Xiang^b

a School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008;
b College of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116

Received:2012-10-12 Revised:2012-11-21 Published:2012-11-26
Supported by:
Project supported by the Natural Science Foundation of Jiangsu Education Department (No. 08KJB150017), the Foundation of Xuzhou Normal University (No. 10XLS02), and the Foundation from National Natural Science Foundation of China for Innovative Research Group (No. 50921002).

A facile and efficient synthesis of novel 2-amino-6-methyl-4-aryltetrahydronaphthalene derivatives by the reaction of aromatic aldehydes, 4-methylcyclohexanone, and malononitrile in the presence of NaOH and 95% EtOH is reported. This protocol has the advantages of shorter reaction time, mild conditions, and easy work-up. The products were identified by ¹H NMR, IR and HRMS techniques. The reported method is the efficient approach for the synthesis of these compounds.

Key words: tetrahydronaphthalene, 4-methylcyclohexanone, malononitrile, multicomponent reaction

Cite this article

Rong Liangce, Wei Xianyong, Zong Zhimin, Han Xiao, Zhang Chengyi, Shen Xiaofeng, Chen Xiang. A Facile and Efficient Synthesis of 2-Amino-6-methyl-4-aryltetrahydronaphthalene Derivatives[J]. Chin. J. Org. Chem., 2013, 33(03): 648-651.

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方便、有效地合成2-氨基-4-芳基-6-甲基四氢化萘衍生物

A Facile and Efficient Synthesis of 2-Amino-6-methyl-4-aryltetrahydronaphthalene Derivatives

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