Cu-Catalyzed Synthesis of Novel Benzo[e]pyrazolo[1,5-c][1,3]-thiazine Derivatives

doi:10.6023/cjoc201407025

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (12): 2478-2486.DOI: 10.6023/cjoc201407025 Previous Articles Next Articles

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Cu催化新型苯并[e]吡唑并[1,5-c][1,3]噻嗪类化合物的合成

李明, 张建薇, 文丽荣

青岛科技大学化学与分子工程学院青岛 266042

收稿日期:2014-07-14 修回日期:2014-08-25 发布日期:2014-09-09
通讯作者: 文丽荣 E-mail:wenlirong@qust.edu.cn
基金资助:
国家自然科学基金(Nos.21072110,21372137)和山东省自然科学基金(No.ZR2012BM003)资助项目.

Cu-Catalyzed Synthesis of Novel Benzo[e]pyrazolo[1,5-c][1,3]-thiazine Derivatives

Li Ming, Zhang Jianwei, Wen Lirong

College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042

Received:2014-07-14 Revised:2014-08-25 Published:2014-09-09
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21072110, 21372137) and the Natural Science Foundation of Shandong Province (No. ZR2012BM003).

1. Cu-Catalyzed Synthesis of Novel Benzo[e]pyrazolo[1,5-c][1,3]-thiazine Derivatives.PDF(1919KB)

Abstract

Based on substrate-design concept, a high chemoselectivitive synthetic strategy of novel benzo[e]pyrazolo[1,5-c][1,3]thiazine compounds through the Cu-catalyzed reactions of 5-(2-bromoaryl)-1H-pyrazol-3-amines and isothiocyanates was developed by using 1-(2-bromoaryl)-3-ethoxy-3-amino-prop-2-en-1-ones as raw material, which has advantages of simple operation, mild reaction conditions and high yields.

Key words: benzo[e]pyrazolo[1,5-c][1,3]thiazines, 1-(2-bromoaryl)-3-ethoxy-3-amino-prop-2-en-1-ones, 5-(2-bromoaryl)-1H-pyrazol-3-amines, isothiocyanates, Cu-catalysis, coupling reaction

Cite this article

Li Ming, Zhang Jianwei, Wen Lirong. Cu-Catalyzed Synthesis of Novel Benzo[e]pyrazolo[1,5-c][1,3]-thiazine Derivatives[J]. Chin. J. Org. Chem., 2014, 34(12): 2478-2486.

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Cu催化新型苯并[e]吡唑并[1,5-c][1,3]噻嗪类化合物的合成

Cu-Catalyzed Synthesis of Novel Benzo[e]pyrazolo[1,5-c][1,3]-thiazine Derivatives

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