First Total Synthesis of (±)-Cycloaltilisin 7 and (±)-Poinsettifolin B

doi:10.6023/cjoc201407047

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (10): 2001-2006.DOI: 10.6023/cjoc201407047 Previous Articles Next Articles

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(±)-Cycloaltilisin 7和(±)-Poinsettifolin B的首次全合成

马晓琴, 杨金会, 冯尧, 陈兵兵, 谢一民

宁夏大学天然气转化国家重点实验室培育基地银川 750021

收稿日期:2014-07-31 修回日期:2014-09-07 发布日期:2014-09-18
通讯作者: 杨金会 E-mail:yang_jh@nxu.edu.cn
基金资助:
国家自然科学基金（Nos. 21362025，21162021）、教育部新世纪优秀人才支持计划（No. NCET-09-0860）资助项目.

First Total Synthesis of (±)-Cycloaltilisin 7 and (±)-Poinsettifolin B

Ma Xiaoqin, Yang Jinhui, Feng Yao, Chen Bingbing, Xie Yimin

Key Laboratory of Energy Sources and Chemical Engineering of Ningxia, Ningxia University, Yinchuan 750021

Received:2014-07-31 Revised:2014-09-07 Published:2014-09-18
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21362025, 21162021) and the Program for New Century Excellent Talents in University (No. NCET-09-0860).

1. First Total Synthesis of (±)-Cycloaltilisin 7 and (±)-Poinsettifolin B.PDF(378KB)

Abstract

Cycloaltilisin 7, isolated from the bud covers of Artocarpus altilis, is a new isoprenyl flavone and has the potential cathepsin K inhibitory activity; while poinsettifolin B is another new geranyl chalcone isolated from the extract of Dorsetenia poinsettifolia, an native cameroonian herb used for the treatment of yaws disease, infection, and other possible skin diseases. Starting from the inexpensive hydroxyl acetophenones and hydroxyl benzaldehydes, the first total syntheses of these two natural products are accomplished with simple and mild conditions. The structures of all new compounds are elucidated by HRMS, ¹H NMR and ¹³C NMR spectra.

Key words: cycloaltilisin 7, poinsettifolin B, flavanoid, chalcone, total synthesis

Cite this article

Ma Xiaoqin, Yang Jinhui, Feng Yao, Chen Bingbing, Xie Yimin. First Total Synthesis of (±)-Cycloaltilisin 7 and (±)-Poinsettifolin B[J]. Chin. J. Org. Chem., 2014, 34(10): 2001-2006.

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(±)-Cycloaltilisin 7和(±)-Poinsettifolin B的首次全合成

First Total Synthesis of (±)-Cycloaltilisin 7 and (±)-Poinsettifolin B

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