Total Synthesis of Longistylin A, Longistylin C and Cajanotone

doi:10.6023/cjoc201410024

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1146-1151.DOI: 10.6023/cjoc201410024 Previous Articles Next Articles

Notes

天然产物Longistylin A, Longistylin C和Cajanotone的全合成

陈文章^a, 王聪^a, 樊玲玲^a, 王建塔^a, 岳炜洲^b, 汤磊^a

a 贵阳医学院药学院贵阳 550004;
b 中国药科大学药学院南京 210009

收稿日期:2014-10-17 修回日期:2014-12-05 发布日期:2015-01-09
通讯作者: 汤磊 E-mail:tlei1974@gmc.edu.cn
基金资助:
教育部新世纪优秀人才支持计划(No.NNCET-12-0656)、贵州省高等学校创新能力提升计划(黔教合协同创新字No.2013-04)、贵州省教育厅青年基金(No.2014-300)资助项目.

Total Synthesis of Longistylin A, Longistylin C and Cajanotone

Chen Wenzhang^a, Wang Cong^a, Fan Lingling^a, Wang Jianta^a, Yue Weizhou^b, Tang Lei^a

a College of Pharmacy, Guiyang Medical University, Guiyang 550004;
b College of Pharmacy, China Pharmaceutical University, Nanjing 210009

Received:2014-10-17 Revised:2014-12-05 Published:2015-01-09
Supported by:
Project supported by the Program for New Century Excellent Talents in University (No.NCET-12-0656), the Innovation Ability Promoting Program in University of Guizhou Province (No.2013-04), the Natural Science Fundation for Youth in Universities of Guizhou Province (No.2014-300).

1. Total Synthesis of Longistylin A, Longistylin C and Cajanotone.PDF(5203KB)

Abstract

Natural products longistylin A, longistylin C and cajanotone belong to stilbenes family and exhibit varieties of bioactivities. Using Horner-Wadsworth-Emmons (HWE) and 1,3-sigma rearrangement reactions as key steps, longistylin A and longistylin C have been successfully synthesized in six steps from 3,5-dimethoxy benzoic acid. Besides, using Barbier and 1,3-sigma rearrangement reactions as key steps, cajanotone has been first prepared in eight steps from 3,5-dihydroxy benzoic acid.

Key words: longistylin A, longistylin C, cajanotone, total synthesis

Cite this article

Chen Wenzhang, Wang Cong, Fan Lingling, Wang Jianta, Yue Weizhou, Tang Lei. Total Synthesis of Longistylin A, Longistylin C and Cajanotone[J]. Chin. J. Org. Chem., 2015, 35(5): 1146-1151.

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天然产物Longistylin A, Longistylin C和Cajanotone的全合成

Total Synthesis of Longistylin A, Longistylin C and Cajanotone

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