Iodine-Catalyzed One-Pot Synthesis of α-Ketoamides from Unsaturated Hydrocarbons

doi:10.6023/cjoc201502014

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (8): 1733-1738.DOI: 10.6023/cjoc201502014 Previous Articles Next Articles

ARTICLE

不饱和烃在碘催化下一锅法合成α-酮酰胺

任相伟, 王光伟, 唐向阳, 赵温涛

天津大学理学院化学系天津 300072

收稿日期:2015-02-08 修回日期:2015-04-08 发布日期:2015-04-10
通讯作者: 赵温涛 E-mail:wentao_Zhao@tju.edu.cn
基金资助:
国家重点基础研究发展计划(No. 2015CB856500)资助项目.

Iodine-Catalyzed One-Pot Synthesis of α-Ketoamides from Unsaturated Hydrocarbons

Ren Xiangwei, Wang Guangwei, Tang Xiangyang, Zhao Wentao

Department of Chemistry, Tianjin University, Tianjin 300072

Received:2015-02-08 Revised:2015-04-08 Published:2015-04-10
Supported by:
Project supported by the National Basic Research Program of China (No. 2015CB856500).

1. Iodine-Catalyzed One-Pot Synthesis of α-Ketoamides from Unsaturated Hydrocarbons.PDF(2619KB)

Abstract

A one-pot synthetic protocol of α-ketoamides from alkene or alkyne using iodine as catalyst and tert-butyl hydroperoxide as oxidant is reported. The protocol has the advantages of good atomic economy, mild reaction condition, high yielding, and avoiding using heavy metal catalyst, which has solved the drawbacks of harsh condition, poor availability of starting materials, and low yielding in previous α-ketoamides systhesis. α-Ketoamides has potential applications in bioactive molecule and drug synthesis.

Key words: α-ketoamide, alkenes, alkynes, iodine, tert-butyl hydroperoxide

Cite this article

Ren Xiangwei, Wang Guangwei, Tang Xiangyang, Zhao Wentao. Iodine-Catalyzed One-Pot Synthesis of α-Ketoamides from Unsaturated Hydrocarbons[J]. Chin. J. Org. Chem., 2015, 35(8): 1733-1738.

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不饱和烃在碘催化下一锅法合成α-酮酰胺

Iodine-Catalyzed One-Pot Synthesis of α-Ketoamides from Unsaturated Hydrocarbons

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