A Facile and New Synthetic Method of Polysubstituted Furans

doi:10.6023/cjoc201503022

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (8): 1739-1745.DOI: 10.6023/cjoc201503022 Previous Articles Next Articles

ARTICLE

一种简便合成多取代呋喃的新方法

邹雯^a, 贺峥嵘^b, 贺峥杰^a

a 南开大学元素有机化学国家重点实验室天津化学化工协同创新中心天津 300071;
b 湖北工程学院化学与材料科学学院孝感 432000

收稿日期:2015-03-16 修回日期:2015-03-30 发布日期:2015-04-10
通讯作者: 贺峥杰 E-mail:zhengjiehe@nankai.edu.cn
基金资助:
国家自然科学基金(Nos. 21272119, 21121002)、湖北省自然科学基金(No. 2007ABA375)资助项目.

A Facile and New Synthetic Method of Polysubstituted Furans

Zou Wen^a, He Zheng-Rong^b, He Zhengjie^a

a State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071;
b College of Chemistry and Material Science, Hubei Engineering University, Xiaogan 432000

Received:2015-03-16 Revised:2015-03-30 Published:2015-04-10
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21272119, 21121002), and the Natural Science Foundation of Hubei Province (No. 2007ABA375).

1. A Facile and New Synthetic Method of Polysubstituted Furans.PDF(3003KB)

Abstract

With the treatment of tributylphosphine and base, alkynoates, aromatic aldehydes and acyl chlorides readily undergo a four-component cascade annulation reaction, giving tri-or tetra-substituted furans in moderate yields. The reaction presumably proceeds through an intramolecular Wittig reaction step of the in situ generated phosphorus ylide intermediate. The annulation reaction features mild reaction conditions and broad substrate scope, and accordingly constitutes a facile and new synthetic method of polysubstituted furans.

Key words: furans, synthesis, phosphines, multicomponent reactions, Wittig reaction

Cite this article

Zou Wen, He Zheng-Rong, He Zhengjie. A Facile and New Synthetic Method of Polysubstituted Furans[J]. Chin. J. Org. Chem., 2015, 35(8): 1739-1745.

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一种简便合成多取代呋喃的新方法

A Facile and New Synthetic Method of Polysubstituted Furans

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