One Step Synthesis of Fluorine-Containing Bicyclicpyridine Compounds

doi:10.6023/cjoc201503019

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (8): 1754-1758.DOI: 10.6023/cjoc201503019 Previous Articles Next Articles

NOTE

含氟双环吡啶类杂环化合物的“一步法”合成

彭美阳^a, 杨瑞霞^a, 刘昔敏^a, 严胜骄^a, 林军^a,b

a 云南大学化学科学与工程学院教育部自然资源药物化学重点实验室昆明 650091;
b 云南大学现代分析测试中心昆明 650091

收稿日期:2015-03-15 修回日期:2015-04-19 发布日期:2015-05-06
通讯作者: 严胜骄, 林军 E-mail:yansj@ynu.edu.cn;linjun@ynu.edu.cn
基金资助:
国家自然科学基金(Nos. U1202221, 21362042, 21262042, 21162037)资助项目.

One Step Synthesis of Fluorine-Containing Bicyclicpyridine Compounds

Peng Meiyang^a, Yang Ruixia^a, Liu Ximin^a, Yan Shengjiao^a, Lin Jun^a,b

a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091;
b Modern Analytical Test Center, Yunnan University, Kunming 650091

Received:2015-03-15 Revised:2015-04-19 Published:2015-05-06
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. U1202221, 21362042, 21262042, 21162037).

1. One Step Synthesis of Fluorine-Containing Bicyclicpyridine Compounds.PDF(3711KB)

Abstract

In this work, one step synthesis of fluorine-containing bicyclic pyridine heterocyclic compounds protocol was established. This method based on the building blocks of β-dicarbonyl compound ethyl 4,4,4-trifluoro-3-oxobutanoate (2) or hexafluoropentane-2,4-dione (3), which reacted with heterocyclic ketene aminals 1 respectively under acetic acid as catalyst and 1,4-dioxane as the solvent. As a result, a series of new fluorinated pyridine compounds 4a~4e and 5a~5e have been synthesized, respectively. The reaction has the advantages of readily available starting materials, simple synthetic route, high yields and simple work-up procedures.

Key words: fluorine-containing, bicyclicpyridine, heterocyclic compounds, acetic acid

Cite this article

Peng Meiyang, Yang Ruixia, Liu Ximin, Yan Shengjiao, Lin Jun. One Step Synthesis of Fluorine-Containing Bicyclicpyridine Compounds[J]. Chin. J. Org. Chem., 2015, 35(8): 1754-1758.

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含氟双环吡啶类杂环化合物的“一步法”合成

One Step Synthesis of Fluorine-Containing Bicyclicpyridine Compounds

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