Recent Advances in Nicotinamide Adenine Dinucluotide (NAD+) Analogs Synthesis and Their Interactions with NAD+-Dependent Enzymes

doi:10.6023/cjoc201508010

Abstract

Interactions between nicotiamide adenine dinucleotide (NAD⁺) and NAD⁺-dependent enzyme play a crucial role in cellular redox state, energy metabolism, catabolism, anabolism and signal transduction. The rules of interaction between NAD⁺and NAD⁺-dependent enzyme have attracted increasing attention due to so many cellular processes are connected to NAD⁺. This review highlights some recent progresses in the fields of NAD⁺analogs synthesis and interactions with NAD⁺- dependent enzyme including the synthesis of NAD⁺analogs and its interactions with wild NAD⁺-dependent enzyme, interactions between NAD⁺and mutant enzymes, interactions between NAD⁺analogs and mutant enzymes.

Key words: NAD⁺, NAD⁺analog, NAD⁺-dependent enzyme, interaction

Cite this article

Hou Shuhua, Qu Zhongguo, Zhong Keli, Bian Yanjiang, Tang Lijun. Recent Advances in Nicotinamide Adenine Dinucluotide (NAD⁺) Analogs Synthesis and Their Interactions with NAD⁺-Dependent Enzymes[J]. Chin. J. Org. Chem., 2016, 36(2): 297-305.

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烟酰胺腺嘌呤二核苷酸(NAD⁺)类似物的合成及与NAD⁺依赖型酶相互作用进展