Review of Total Synthesis of Valienamine

doi:10.6023/cjoc201605015

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (12): 2771-2785.DOI: 10.6023/cjoc201605015 Previous Articles Next Articles

REVIEW

有效霉烯胺的化学合成进展

计立^a,b, 吴国锋^b, 叶伟东^b, 陈新志^a

a 浙江大学化学工程与生物工程学院杭州 310027;
b 浙江医药股份有限公司研究院新昌 312500

收稿日期:2016-05-11 修回日期:2016-07-08 发布日期:2016-08-10
通讯作者: 陈新志 E-mail:xzchen@zju.edu.cn
基金资助:
国家自然科学基金（Nos. 21376213，21476194）、教育部高等学校博士学科点专项科研基金（No. 20120101110062）、浙江省博士后科研项目择优（No. BSH1502096）资助项目.

Review of Total Synthesis of Valienamine

Ji Li^a,b, Wu Guofeng^b, Ye Weidong^b, Chen Xinzhi^a

a College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027;
b Research & Development Center, Zhejiang Medicine Co., Ltd, Xinchang 312500

Received:2016-05-11 Revised:2016-07-08 Published:2016-08-10
Supported by:
Project supported by the National Science Foundation of China (Nos. 21376213, 21476194), the Doctoral Program of Higher Education of China (No. 20120101110062), and the Postdoctoral Advanced Programs of Zhejiang Province (No. BSH1502096).

Valienamine is an α-glucosidase inhibitor belonging to C₇N aminocyclitols that was isolated from the microbial degradation of validoxylamine A with Pseudomonas denitrificans. Moreover, valienamine is also an essential core unit in many kinds of pseudo-oligosaccharidic α-D-glucosidase inhibitors such as validamycins and acarbose. Due to the unique structural feature and interesting biological property, since the first isolation in 1972, a great deal of effort has been devoted to the development of various approaches for the efficient synthesis of valienamine. This review summarizes the 23 synthetic approaches towards valienamine reported in the last thirty years.

Key words: valienamine, C₇N aminocyclitols, amino-carbasugars, α-glucosidase inhibitors, total synthesis

Cite this article

Ji Li, Wu Guofeng, Ye Weidong, Chen Xinzhi. Review of Total Synthesis of Valienamine[J]. Chin. J. Org. Chem., 2016, 36(12): 2771-2785.

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有效霉烯胺的化学合成进展

Review of Total Synthesis of Valienamine

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