Efficient Hydrolysis of Haloalkynes to α-Haloketones in Ionic Liquid

doi:10.6023/cjoc201610031

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (6): 1501-1505.DOI: 10.6023/cjoc201610031 Previous Articles Next Articles

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离子液体中卤代炔烃高效水解制取α-卤代甲基酮的研究

付文强^a, 谭平^b, 邓伟^a, 向建南^a

a. 湖南大学化学化工学院化学生物传感与计量学国家重点实验室长沙 410082;
b. 湖南机电职业技术学院长沙 410151

收稿日期:2016-10-18 修回日期:2016-12-30 发布日期:2017-01-20
通讯作者: 向建南 E-mail:jnxiang@hnu.edu.cn
基金资助:
湖南省科技厅基金（No.2015WK3003）、湖南省教育厅科研基金（No.14C0405）资助项目.

Efficient Hydrolysis of Haloalkynes to α-Haloketones in Ionic Liquid

Fu Wenqiang^a, Tan Ping^b, Deng Wei^a, Xiang Jiannan^a

a. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering,Hunan University, Changsha 410082;
b. Hunan Mechanical and Electrical Polytechnic, Changsha 410151

Received:2016-10-18 Revised:2016-12-30 Published:2017-01-20
Contact: 10.6023/cjoc201610031 E-mail:jnxiang@hnu.edu.cn
Supported by:
Project supported by the Planned Science and Technology Project of Hunan Province (No. 2015WK3003), the Scientific Research Fund of Hunan Provincial Education Department (No. 14C0405).

1. Efficient Hydrolysis of Haloalkynes to α-Haloketones in Ionic Liquid.PDF(2077KB)

Abstract

The haloalkynes were hydrolyzed to α-haloketones by sulfuric acid promotion in ionic liquids (ILs) with 85%~94% yields. The ILs-H₂SO₄ reaction system could be easily recycled (more five times) without any effect for reaction yield. At the same time, a wide scope of substrates haloalkynes were proper in this reaction system and a series of α-chloro/bromo/iodo acetophenones with different substituent (such as methyl, methoxyl, hydroxyl, nitro etc.) and aliphatic α-haloketones have been obtained in good yields.

Key words: ionic liquid, haloalkynes, hydration, α-haloketones, recyclable

Cite this article

Fu Wenqiang, Tan Ping, Deng Wei, Xiang Jiannan. Efficient Hydrolysis of Haloalkynes to α-Haloketones in Ionic Liquid[J]. Chin. J. Org. Chem., 2017, 37(6): 1501-1505.

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离子液体中卤代炔烃高效水解制取α-卤代甲基酮的研究

Efficient Hydrolysis of Haloalkynes to α-Haloketones in Ionic Liquid

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