Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (7): 2229-2235.DOI: 10.6023/cjoc202202007 Previous Articles     Next Articles



李海琼, 尹梦云, 谢芬芬, 张正兵*(), 韩盼*(), 敬林海*()   

  1. 西华师范大学化学化工学院 化学合成与污染控制四川省重点实验室 四川南充 637002
  • 收稿日期:2022-02-06 修回日期:2022-03-11 发布日期:2022-08-09
  • 通讯作者: 张正兵, 韩盼, 敬林海
  • 作者简介:
  • 基金资助:
    国家自然科学基金(22001217); 四川省科技厅(2021ZYD0064); 西华师范大学英才基金(17YC020); 西华师范大学基本科研业务费(19D037); 西华师范大学基本科研业务费(19E034)

Synthesis of Nitrile via Electrochemical Appel Reaction

Haiqiong Li, Mengyun Yin, Fenfen Xie, Zhengbing Zhang(), Pan Han(), Linhai Jing()   

  1. Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, Sichuan 637002
  • Received:2022-02-06 Revised:2022-03-11 Published:2022-08-09
  • Contact: Zhengbing Zhang, Pan Han, Linhai Jing
  • About author:
    These authors contributed equally to this work
  • Supported by:
    National Natural Science Foundation of China(22001217); Science and Technology Program of Sichuan Province(2021ZYD0064); Meritocracy Research Funds of China West Normal University(17YC020); Fundamental Research Funds of China West Normal University(19D037); Fundamental Research Funds of China West Normal University(19E034)

An electrochemical Appel reaction was developed for the synthesis of nitriles. This protocol features operationally simplicity, mild reaction conditions and environmental friendliness, enabling synthesis of various aromatic and aliphatic nitriles. Based on the controlled experiments and cyclic voltammetry (CV) experimental results, an electrochemical Appel reaction mechanism was proposed to explain the reaction process.

Key words: electrochemical synthesis, Appel reaction, dehydration of oximes, synthesis of nitriles