Progress in Synthesis of Thiopeptide Antibiotics Analogues

doi:10.6023/cjoc201702017

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1653-1666.DOI: 10.6023/cjoc201702017 Previous Articles Next Articles

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硫肽类抗生素类似物合成进展

王守锋^a,b, 郑庆飞^c, 段盼盼^c, 刘文^c

a. 济南大学化学化工学院济南 250022;
b. 山东省氟化学化工材料重点实验室济南 250022;
c. 中国科学院上海有机化学研究所生命有机化学国家重点实验室上海 200032

收稿日期:2017-02-15 修回日期:2017-03-20 发布日期:2017-04-10
通讯作者: 王守锋, 刘文 E-mail:chm_wangsf@ujn.edu.cn;wliu@sioc.ac.cn
基金资助:
国家自然科学基金（No.31430005）、山东省自然科学基金（No.ZR2016HM44）资助项目.

Progress in Synthesis of Thiopeptide Antibiotics Analogues

Wang Shoufeng^a,b, Zheng Qingfei^c, Duan Panpan^c, Liu wen^c

a. College of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022;
b. Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, University of Jinan, Jinan 250022;
c. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032

Received:2017-02-15 Revised:2017-03-20 Published:2017-04-10
Contact: 10.6023/cjoc201702017 E-mail:chm_wangsf@ujn.edu.cn;wliu@sioc.ac.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No.31430005) and the Natural Science Foundation of Shandong Province (No.ZR2016HM44).

Thiopeptide antibiotics, which are a growing class of sulfur-rich and highly modified polyazolyl peptide natural products, have been appreciated because of their complex structures, potent biological activities and unusual modes of action. Recently, a great deal of effort has been devoted to the development of various approaches for the efficient synthesis of thiopeptide antibiotics analogues. This review summarizes synthetic approaches towards thiopeptide antibiotics analogues via semisynthesis, combinatorial biosynthesis and precursor-directed mutasynthesis.

Key words: thiopeptide antibiotics analogue, semisynthesis, combinatorial biosynthesis, precursor-directed mutasynthesis

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Wang Shoufeng, Zheng Qingfei, Duan Panpan, Liu wen. Progress in Synthesis of Thiopeptide Antibiotics Analogues[J]. Chin. J. Org. Chem., 2017, 37(7): 1653-1666.

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硫肽类抗生素类似物合成进展

Progress in Synthesis of Thiopeptide Antibiotics Analogues

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