Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster

doi:10.6023/cjoc201702043

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (5): 1295-1299.DOI: 10.6023/cjoc201702043 Previous Articles Next Articles

Notes

手性多齿胺膦配体/铁簇合物催化酮的不对称转移氢化反应

吴访, 张文景, 安冬丽, 李岩云, 高景星

厦门大学化学化工学院醇醚酯化工清洁生产国家工程实验室厦门 361005

收稿日期:2017-02-27 修回日期:2017-04-01 发布日期:2017-04-13
通讯作者: 李岩云 E-mail:yanyunli@xmu.edu.cn
基金资助:
国家自然科学基金（Nos.21173176，21673190）、中央高校基本科研业务费专项资金（No.20720150040）资助项目.

Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster

Wu Fang, Zhang Wenjing, An Dongli, Li Yanyun, Gao Jingxing

National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005

Received:2017-02-27 Revised:2017-04-01 Published:2017-04-13
Contact: 10.6023/cjoc201702043 E-mail:yanyunli@xmu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21173176, 21673190) and the Fundamental Research Funds for the Central Universities (No. 20720150040).

1. Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster.PDF(337KB)

Abstract

As one of the most abundant metals on earth, iron is cheap and low toxicity. Herein we reported the asymmetric transfer hydrogenation of (ATH) ketones catalyzed by the system generated in situ from chiral multidentate aminophosphine ligand (R,R,R,R)-PN₄H₆ and Fe₃(CO)₁₂. The effects of temperature and additive on the ATH of propiophenone were examined. After optimizing the reaction conditions, we applied the catalytic system to the ATH of various aromatic ketones, obtaining the corresponding optical active alcohols with high enantioselectivities (up to 96% ee).

Key words: chiral aminophosphine ligand, iron cluster, cheap metal, ketones, asymmetric transfer hydrogenation

Cite this article

Wu Fang, Zhang Wenjing, An Dongli, Li Yanyun, Gao Jingxing. Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster[J]. Chin. J. Org. Chem., 2017, 37(5): 1295-1299.

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手性多齿胺膦配体/铁簇合物催化酮的不对称转移氢化反应

Asymmetric Transfer Hydrogenation of Ketones Catalyzed by Chiral Multidentate Aminophosphine Ligands/Iron Cluster

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