Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2159-2164.DOI: 10.6023/cjoc201612058 Previous Articles     Next Articles

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高温水中2-甲基喹啉及2-甲基吡啶与芳醛的反应研究

肖尚友, 毕旌富, 穆小静, 周曌, 徐广   

  1. 重庆大学化学化工学院 重庆 400030
  • 收稿日期:2016-12-25 修回日期:2017-03-29 发布日期:2017-04-18
  • 通讯作者: 肖尚友 E-mail:xsy6508@163.com

Reaction of 2-Methylquinoline and 2-Methylpyridine with Aromatic Aldehydes in High Temperature Water

Xiao Shangyou, Bi Jingfu, Mu Xiaojing, Zhou Zhao, Xu Guang   

  1. College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030
  • Received:2016-12-25 Revised:2017-03-29 Published:2017-04-18
  • Contact: 10.6023/cjoc201612058 E-mail:xsy6508@163.com

Alkyl aza-arene derivatives were synthesized in high-temperature water without catalyst. The effects of temperature, reaction time, molar ratio of reactants and amount of water on the reaction were investigated. The results indicate that it is an efficient way to synthesize 2-methylquinoline derivatives and 2-methylpyridine derivatives from 2-methylquinoline and 2-methylpyridine with various aromatic aldehydes by C-H bond activation. This process is clean and easy to operate.

Key words: aza-arene derivatives, 2-methylquinoline, 2-methylpyridine, aldehyde, high-temperature water