Synthesis and Anti-tumor Activities against HepG2 Cell in vitro of the Conjugates of Honokiol, Quercetin and Berberine

doi:10.6023/cjoc201801023

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1549-1555.DOI: 10.6023/cjoc201801023 Previous Articles Next Articles

Notes

小檗碱与和厚朴酚及槲皮素缀合物的合成及其体外抗肝癌HepG2细胞活性评价

廖世莉^a, 张国改^a, 曹涵^a, 陈碧莹^a, 李卫民^b, 吴霞^a, 冯毅凡^a

a 广东药科大学中心实验室广州 510000;
b 广州中医药大学中药学院广州 510000

收稿日期:2018-01-26 修回日期:2018-02-27 发布日期:2018-03-08
通讯作者: 李卫民,E-mail:13925023915@139.com;吴霞,E-mail:wxiaxia@163.com;冯毅凡,E-mail:yffeng@139.com E-mail:13925023915@139.com;wxiaxia@163.com;yffeng@139.com
基金资助:
国家自然科学基金（Nos.21275036，81202429）资助项目.

Synthesis and Anti-tumor Activities against HepG2 Cell in vitro of the Conjugates of Honokiol, Quercetin and Berberine

Liao Shili^a, Zhang Guogai^a, Cao Han^a, Chen Biying^a, Li Weimin^b, Wu Xia^a, Feng Yifan^a

a Central Laboratory, Guangdong Pharmaceutical University, Guangzhou 510000;
b College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510000

Received:2018-01-26 Revised:2018-02-27 Published:2018-03-08
Contact: 10.6023/cjoc201801023 E-mail:13925023915@139.com;wxiaxia@163.com;yffeng@139.com
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21275036, 81202429).

1. Synthesis and Anti-tumor Activities against HepG2 Cell in vitro of the Conjugates of Honokiol, Quercetin and Berberine.PDF(1495KB)

Abstract

Berberine, honokiol, quercetin are the lead compounds with outstanding anti-tumor activities. Three novel products were synthesized from honokiol, quercetin and berberine. The structures of the products were firstly confirmed by ¹H NMR, ¹³C NMR, 2D NMR, HRMS, IR and UV. All products were evaluated for their anti-tumor activities against HepG2 cell in vitro and the results showed that the inhibitory effects of two compounds on HepG2 cell were far superior to honokiol and berberine hydrochloride, and the anti-tumor activities were similar to the reference drug cisplatin. It means that compounds 1 and 2 are expected to be the potential anti-tumor drugs.

Key words: berberine, honokiol, quercetin, anti-tumor activity

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Liao Shili, Zhang Guogai, Cao Han, Chen Biying, Li Weimin, Wu Xia, Feng Yifan. Synthesis and Anti-tumor Activities against HepG2 Cell in vitro of the Conjugates of Honokiol, Quercetin and Berberine[J]. Chin. J. Org. Chem., 2018, 38(6): 1549-1555.

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小檗碱与和厚朴酚及槲皮素缀合物的合成及其体外抗肝癌HepG2细胞活性评价

Synthesis and Anti-tumor Activities against HepG2 Cell in vitro of the Conjugates of Honokiol, Quercetin and Berberine

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