Methods and Strategies for the Synthesis of Peduncularine

doi:10.6023/cjoc201810008

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (1): 47-58.DOI: 10.6023/cjoc201810008 Previous Articles Next Articles

Special Issue: 庆祝陈庆云院士九十华诞

Reviews

生物碱Peduncularine的合成策略和方法

章玉平^a, 田学超^a, 张岩^b, 洪然^b, 黄莎华^a,b

a 上海应用技术大学化学与环境工程学院上海 201418;
b 中国科学院上海有机化学研究所中国科学院天然产物有机合成化学重点实验室分子合成卓越创新中心上海 200032

收稿日期:2018-10-09 修回日期:2018-11-22 发布日期:2018-12-05
通讯作者: 洪然, 黄莎华 E-mail:rhong@sioc.ac.cn;shahua@sit.edu.cn
基金资助:
国家自然科学基金（No.21402121）和上海应用技术大学协同创新计划（No.XTCX2015-16）项目资助.

Methods and Strategies for the Synthesis of Peduncularine

Zhang Yuping^a, Tian Xuechao^a, Zhang Yan^b, Hong Ran^b, Huang Shahua^a,b

a School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418;
b CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received:2018-10-09 Revised:2018-11-22 Published:2018-12-05
Contact: 10.6023/cjoc201810008 E-mail:rhong@sioc.ac.cn;shahua@sit.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21402121) and the Collaborative Innovation Program of Shanghai Institute of Technology (No. XTCX2015-16).

(-)-Peduncularine is the principal alkaloid isolated from Tasmanian shrub Aristotelia peduncularis. Due to its unusual 6-azabicyclo[3.2.1]octane core, the indole alkaloid was received numerous attention from the synthetic community and several innovative synthetic strategies have been developed. In this minireview, the synthetic efforts of peduncularine are summarized as inspiration for future development of medicinally interesting derivatives.

Key words: 6-azabicyclo[3.2.1]octane, cyclization, indole alkaloids, peduncularine, total synthesis

Cite this article

Zhang Yuping, Tian Xuechao, Zhang Yan, Hong Ran, Huang Shahua. Methods and Strategies for the Synthesis of Peduncularine[J]. Chin. J. Org. Chem., 2019, 39(1): 47-58.

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生物碱Peduncularine的合成策略和方法

Methods and Strategies for the Synthesis of Peduncularine

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