Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (1): 47-58.DOI: 10.6023/cjoc201810008 Previous Articles     Next Articles

Special Issue: 庆祝陈庆云院士九十华诞



章玉平a, 田学超a, 张岩b, 洪然b, 黄莎华a,b   

  1. a 上海应用技术大学化学与环境工程学院 上海 201418;
    b 中国科学院上海有机化学研究所 中国科学院天然产物有机合成化学重点实验室 分子合成卓越创新中心 上海 200032
  • 收稿日期:2018-10-09 修回日期:2018-11-22 发布日期:2018-12-05
  • 通讯作者: 洪然, 黄莎华;
  • 基金资助:


Methods and Strategies for the Synthesis of Peduncularine

Zhang Yupinga, Tian Xuechaoa, Zhang Yanb, Hong Ranb, Huang Shahuaa,b   

  1. a School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418;
    b CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2018-10-09 Revised:2018-11-22 Published:2018-12-05
  • Contact: 10.6023/cjoc201810008;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21402121) and the Collaborative Innovation Program of Shanghai Institute of Technology (No. XTCX2015-16).

(-)-Peduncularine is the principal alkaloid isolated from Tasmanian shrub Aristotelia peduncularis. Due to its unusual 6-azabicyclo[3.2.1]octane core, the indole alkaloid was received numerous attention from the synthetic community and several innovative synthetic strategies have been developed. In this minireview, the synthetic efforts of peduncularine are summarized as inspiration for future development of medicinally interesting derivatives.

Key words: 6-azabicyclo[3.2.1]octane, cyclization, indole alkaloids, peduncularine, total synthesis