FeCl2-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle

doi:10.6023/cjoc201912041

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1697-1703.DOI: 10.6023/cjoc201912041 Previous Articles Next Articles

O₂参与下FeCl₂催化的分子内氧化反应构建异噁唑杂环

阿布力米提·阿布都卡德尔, 汪荣, 买尔哈巴·买买提, 刘晨江

新疆大学化学化工学院乌鲁木齐 830046

收稿日期:2019-12-18 修回日期:2020-02-05 发布日期:2020-03-04
通讯作者: 阿布力米提·阿布都卡德尔, 刘晨江 E-mail:ablimit1970@126.com;pxylcj@126.com
基金资助:
国家自然科学基金（No.21562039）资助项目.

FeCl₂-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle

Abdukader Ablimit, Wang Rong, Mamat Marhaba, Liu Chenjiang

College of Chemical and Chemical Engineering, Xinjiang University, Urumqi 830046

Received:2019-12-18 Revised:2020-02-05 Published:2020-03-04
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21562039).

1. 201697S.pdf(2202KB)

Abstract

A simple, practical and highly efficient synthesis of multi substituted isoxazole derivatives via cheap metal salt FeCl₂-catalyzed direct aerobic oxidative has been developed. Nineteen novel multi-substituted 3,5-diaryl isoxazole derivtaves were synthesized and a single crystal was successfully cultivated. The products were get with about 70%~90% yields under mild conditions. The structures of products were fully characterized by ¹H NMR, ¹³C NMR, elemental analysis and X-ray crystal.

Key words: iron catalysis, oxygen oxidation, isoxazole, heterocycle, N-O bond formation

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Abdukader Ablimit, Wang Rong, Mamat Marhaba, Liu Chenjiang. FeCl₂-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle[J]. Chinese Journal of Organic Chemistry, 2020, 40(6): 1697-1703.

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O₂参与下FeCl₂催化的分子内氧化反应构建异噁唑杂环

FeCl₂-Catalyzed Intramolecular Aerobic Reaction for Construction of Isoxazoles Heterocycle

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O2参与下FeCl2催化的分子内氧化反应构建异噁唑杂环