Synthesis of Key Intermediate of Cyathane Diterpenes

doi:10.6023/cjoc201912037

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 2148-2152.DOI: 10.6023/cjoc201912037 Previous Articles Next Articles

鸟巢烷二萜关键中间体的合成

李若馨, 韩锐, 高锦明

西北农林科技大学化学与药学院陕西省天然产物化学生物学重点实验室陕西杨陵 712100

收稿日期:2019-12-25 修回日期:2020-04-09 发布日期:2020-04-23
通讯作者: 高锦明 E-mail:jinminggao@nwsuaf.edu.cn

Synthesis of Key Intermediate of Cyathane Diterpenes

Li Ruoxin, Han Rui, Gao Jinming

Shanxi Key Laboratory of Natural Products Chemistry and Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100

Received:2019-12-25 Revised:2020-04-09 Published:2020-04-23

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Abstract

A synthetic plan of bicyclo[5/6] key intermediate of cyathane is reported. All the involved reactions, such as nucleophilic substitution reaction, radical ring-closing reaction, Johnson-Claisen rearrangement and Grignard addition, were optimized for higher yields. The procedure provides a simple and efficient method for the synthesis of bicyclo-key intermediate of cyathane. It is expected to have wide applications in the synthesis of cyathane.

Key words: cyathane diterpenes, natural product, nucleophilic substitution, Claisen rearrangement

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Li Ruoxin, Han Rui, Gao Jinming. Synthesis of Key Intermediate of Cyathane Diterpenes[J]. Chinese Journal of Organic Chemistry, 2020, 40(7): 2148-2152.

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鸟巢烷二萜关键中间体的合成

Synthesis of Key Intermediate of Cyathane Diterpenes

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