Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (9): 2626-2640.DOI: 10.6023/cjoc202004002 Previous Articles     Next Articles


孙晓华, 孙传策, 冯立军, 康从民   

  1. 青岛科技大学化工学院 山东青岛 266042
  • 收稿日期:2020-04-01 修回日期:2020-05-31 发布日期:2020-06-20
  • 通讯作者: 康从民
  • 基金资助:

Recent Progress in the Synthesis of Thieno[2,3-d]pyrimidine Compounds via Tandem Cyclization

Sun Xiaohua, Sun Chuance, Feng Lijun, Kang Congmin   

  1. College of Chemical Engineering, Qingdao University of Science and Technology, Shandong Province, Qingdao, Shandong 266042
  • Received:2020-04-01 Revised:2020-05-31 Published:2020-06-20
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21272131).

Thieno[2,3-d]pyrimidine compounds are an important class of organic synthesis intermediates and pharmacologically active molecules, which not only have broad medical application prospect, but also worth researching. Therefore the synthesis of them has attracted much attention. The previous methods mainly apply tandem cyclization or one-pot multi-com-ponent reaction combined with microwave-assisted reaction or new catalysts to reach the purpose of shortening reaction time, reducing steps, enhancing yields and lowering costs. In this paper, the recent progress in the synthesis of thieno[2,3-d]pyri-midine compounds via tandem cyclization in recent ten years, especially in the latest five years, is reviewed. The problems and limitations faced are discussed, and the development directions are also prospected.

Key words: thieno[2,3-d]pyrimidine, tandem cyclization, microwave reaction, one-pot multi-component reaction