Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (5): 2001-2007.DOI: 10.6023/cjoc202010036 Previous Articles Next Articles
ARTICLES
彭福涛a, 黄立梁a, 黄军海b,*(), 冯煌迪a,*()
收稿日期:
2020-10-28
修回日期:
2020-12-30
发布日期:
2021-02-07
通讯作者:
黄军海, 冯煌迪
基金资助:
Futao Penga, Liliang Huanga, Junhai Huangb,*(), Huangdi Fenga,*()
Received:
2020-10-28
Revised:
2020-12-30
Published:
2021-02-07
Contact:
Junhai Huang, Huangdi Feng
About author:
Supported by:
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Futao Peng, Liliang Huang, Junhai Huang, Huangdi Feng. Double aza-Morita-Baylis-Hillman Domino Reaction to Access Amino Derived 1,6-Dienes[J]. Chinese Journal of Organic Chemistry, 2021, 41(5): 2001-2007.
Entry | Ratio of 1a/2a/3a | Additive | Solvent (V:V) | Yieldb/% |
---|---|---|---|---|
1 | 0.5:2.0:3.0 | DABCO | Toluene | 45 |
2 | 0.5:2.0:3.0 | DBU | Toluene | 18 |
3 | 0.5:2.0:3.0 | DIEPA | Toluene | 12 |
4 | 0.5:2.0:3.0 | DMEDA | Toluene | 11 |
5 | 0.5:2.0:3.0 | DMAP | Toluene | 15 |
6 | 0.5:2.0:3.0 | PPh3 | Toluene | 20 |
7 | 0.5:2.0:3.0 | P(C5H11)3 | Toluene | 5 |
8 | 0.5:2.0:3.0 | DABCO | DMSO | 19 |
9 | 0.5:2.0:3.0 | DABCO | Dioxane | 9 |
10 | 0.5:2.0:3.0 | DABCO | THF | 40 |
11 | 0.5:2.0:3.0 | DABCO | EtOH | 30 |
12 | 0.5:2.0:3.0 | DABCO | CH3CN | 18 |
13 | 0.5:1.0:3.0 | DABCO | Toluene | 6 |
14 | 0.5:1.5:3.0 | DABCO | Toluene | 31 |
15 | 0.5:2.5:3.0 | DABCO | Toluene | 67 |
16 | 0.5:2.5:2.5 | DABCO | Toluene | 52 |
17 | 0.5:2.5:3.5 | DABCO | Toluene | 40 |
18c | 0.5:2.5:3.0 | DABCO | Toluene | 81 |
19 | 0.5:2.5:3.0 | DABCO | Toluene/H2O (24:1) | 80 |
20 | 0.5:2.5:3.0 | DABCO | Toluene/H2O (16:1) | 85 |
21 | 0.5:2.5:3.0 | DABCO | Toluene/H2O (8:1) | 65 |
22d | 0.5:2.5:3.0 | DABCO | Toluene | 0 |
Entry | Ratio of 1a/2a/3a | Additive | Solvent (V:V) | Yieldb/% |
---|---|---|---|---|
1 | 0.5:2.0:3.0 | DABCO | Toluene | 45 |
2 | 0.5:2.0:3.0 | DBU | Toluene | 18 |
3 | 0.5:2.0:3.0 | DIEPA | Toluene | 12 |
4 | 0.5:2.0:3.0 | DMEDA | Toluene | 11 |
5 | 0.5:2.0:3.0 | DMAP | Toluene | 15 |
6 | 0.5:2.0:3.0 | PPh3 | Toluene | 20 |
7 | 0.5:2.0:3.0 | P(C5H11)3 | Toluene | 5 |
8 | 0.5:2.0:3.0 | DABCO | DMSO | 19 |
9 | 0.5:2.0:3.0 | DABCO | Dioxane | 9 |
10 | 0.5:2.0:3.0 | DABCO | THF | 40 |
11 | 0.5:2.0:3.0 | DABCO | EtOH | 30 |
12 | 0.5:2.0:3.0 | DABCO | CH3CN | 18 |
13 | 0.5:1.0:3.0 | DABCO | Toluene | 6 |
14 | 0.5:1.5:3.0 | DABCO | Toluene | 31 |
15 | 0.5:2.5:3.0 | DABCO | Toluene | 67 |
16 | 0.5:2.5:2.5 | DABCO | Toluene | 52 |
17 | 0.5:2.5:3.5 | DABCO | Toluene | 40 |
18c | 0.5:2.5:3.0 | DABCO | Toluene | 81 |
19 | 0.5:2.5:3.0 | DABCO | Toluene/H2O (24:1) | 80 |
20 | 0.5:2.5:3.0 | DABCO | Toluene/H2O (16:1) | 85 |
21 | 0.5:2.5:3.0 | DABCO | Toluene/H2O (8:1) | 65 |
22d | 0.5:2.5:3.0 | DABCO | Toluene | 0 |
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