Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (1): 160-171.DOI: 10.6023/cjoc202106028 Previous Articles Next Articles
ARTICLES
收稿日期:
2021-06-17
修回日期:
2021-09-03
发布日期:
2021-09-26
通讯作者:
王兰芝
基金资助:
Mingliang Wang, Liuyan Yin, Tiantian Wen, Xiao Zhang, Jie Gao, Lanzhi Wang()
Received:
2021-06-17
Revised:
2021-09-03
Published:
2021-09-26
Contact:
Lanzhi Wang
Supported by:
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Mingliang Wang, Liuyan Yin, Tiantian Wen, Xiao Zhang, Jie Gao, Lanzhi Wang. Green Synthesis of 1,5-Benzodiazepines with Multifunctional Groups[J]. Chinese Journal of Organic Chemistry, 2022, 42(1): 160-171.
Entry | Solvent | Temp./℃ | Catalystb | Time/h | Yielde/% |
---|---|---|---|---|---|
1 | EtOH | 0 | Free | 12.0 | — |
2 | EtOH | Refluxc | Free | 8.0 | 20 |
3 | EtOH | r.t.d | Free | 10.0 | 40 |
4 | MeOH | r.t. | Free | 10.0 | 35 |
5 | MeCN | r.t. | Free | 13.0 | 30 |
6 | PhMe | r.t. | Free | 13.0 | 25 |
7 | DMF | r.t. | Free | 13.0 | 32 |
8 | THF | r.t. | Free | 13.0 | 30 |
9 | EtOH | r.t. | AcOH | 3.0 | 50 |
10 | EtOH | r.t. | PTSA | 3.0 | 50 |
11 | EtOH | r.t. | PMA | 4.0 | 53 |
12 | EtOH | r.t. | PWA | 4.0 | 55 |
13 | EtOH | r.t. | CoCl2 | 5.5 | 65 |
14 | EtOH | r.t. | CeCl3 | 5.5 | 65 |
15 | EtOH | r.t. | CoFe2O4 | 5.5 | 78 |
Entry | Solvent | Temp./℃ | Catalystb | Time/h | Yielde/% |
---|---|---|---|---|---|
1 | EtOH | 0 | Free | 12.0 | — |
2 | EtOH | Refluxc | Free | 8.0 | 20 |
3 | EtOH | r.t.d | Free | 10.0 | 40 |
4 | MeOH | r.t. | Free | 10.0 | 35 |
5 | MeCN | r.t. | Free | 13.0 | 30 |
6 | PhMe | r.t. | Free | 13.0 | 25 |
7 | DMF | r.t. | Free | 13.0 | 32 |
8 | THF | r.t. | Free | 13.0 | 30 |
9 | EtOH | r.t. | AcOH | 3.0 | 50 |
10 | EtOH | r.t. | PTSA | 3.0 | 50 |
11 | EtOH | r.t. | PMA | 4.0 | 53 |
12 | EtOH | r.t. | PWA | 4.0 | 55 |
13 | EtOH | r.t. | CoCl2 | 5.5 | 65 |
14 | EtOH | r.t. | CeCl3 | 5.5 | 65 |
15 | EtOH | r.t. | CoFe2O4 | 5.5 | 78 |
Entry | Solvent | Temp./℃ | Catalystb | Time/h | Yieldc/% |
---|---|---|---|---|---|
1 | EtOH | r.t.d | Free | 5.5 | 80 |
2 | EtOH | r.t. | AcOH | 3.5 | 50 |
3 | EtOH | r.t. | PTSA | 3.5 | 50 |
4 | EtOH | r.t. | PMA | 5.0 | 50 |
5 | EtOH | r.t. | PWA | 5.0 | 55 |
6 | EtOH | r.t. | CoCl2 | 6.0 | 65 |
7 | EtOH | r.t. | CeCl3 | 6.0 | 65 |
8 | EtOH | r.t. | CoFe2O4 | 6.0 | 70 |
Entry | Solvent | Temp./℃ | Catalystb | Time/h | Yieldc/% |
---|---|---|---|---|---|
1 | EtOH | r.t.d | Free | 5.5 | 80 |
2 | EtOH | r.t. | AcOH | 3.5 | 50 |
3 | EtOH | r.t. | PTSA | 3.5 | 50 |
4 | EtOH | r.t. | PMA | 5.0 | 50 |
5 | EtOH | r.t. | PWA | 5.0 | 55 |
6 | EtOH | r.t. | CoCl2 | 6.0 | 65 |
7 | EtOH | r.t. | CeCl3 | 6.0 | 65 |
8 | EtOH | r.t. | CoFe2O4 | 6.0 | 70 |
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