Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (7): 2147-2173.DOI: 10.6023/cjoc202401036 Previous Articles     Next Articles

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碳酸亚乙烯酯: 有机合成化学中的多功能合成子

林雨, 付海峰, 曹华, 刘想*()   

  1. 广东药科大学医药化工学院 广东省化妆品工程技术研究中心 中山 528458
  • 收稿日期:2024-01-30 修回日期:2024-03-05 发布日期:2024-03-28
  • 基金资助:
    广东药科大学启动基金(51361303); 广东药科大学启动基金(51361304)

Vinylene Carbonate: A Versatile Synthon in Organic Synthetic Chemistry

Yu Lin, Haifeng Fu, Hua Cao, Xiang Liu()   

  1. School of Chemistry and Chemical Engineering and Guangdong Cosmetics Engineering & Technology Research Center, Guangdong Pharmaceutical University, Zhongshan 528458
  • Received:2024-01-30 Revised:2024-03-05 Published:2024-03-28
  • Contact: E-mail: liux96@gdpu.edu.cn
  • Supported by:
    Start-Up Grant from Guangdong Pharmaceutical University(51361303); Start-Up Grant from Guangdong Pharmaceutical University(51361304)

In recent years, vinylene carbonate has become a new and ideal multifunctional synthon, which is widely used in a variety of organic transformations. Especially in the field of transition metal-catalyzed C—H functionalization, it can be used to construct target molecules containing carbon and heterocyclic skeletons. Since Nishii and Miura first reported that vinylene carbonate participates in coupling reactions as an “ethynol surrogate” in 2009, it has been successively reported as an “acetylene surrogate”, “C1 synthon”, “acylmethylation reagent”, and others. These developments not only highlight the multifunctional transformation of vinylene carbonate, but also provide new ideas for the synthesis of complex compounds. The latest research progress of vinylene carbonate in recent years is summarized and the prospects for its future development based on the different reaction roles of vinylene carbonate in synthetic chemistry are proposed.

Key words: vinyl carbonate, C—H functionalization, cyclization, N-heterocycles