化学学报 ›› 2019, Vol. 77 ›› Issue (4): 340-350.DOI: 10.6023/A18100414 上一篇    下一篇

综述

口腔癌相关唾液肿瘤生物标志物的分析检测研究进展

金鑫, 王晓英   

  1. 东南大学公共卫生学院 环境医学工程教育部重点实验室 南京 210009
  • 投稿日期:2018-10-07 发布日期:2018-12-05
  • 通讯作者: 王晓英 E-mail:wxy@seu.edu.cn
  • 作者简介:金鑫,东南大学公共卫生学院2017级在读硕士,研究方向为肿瘤相关标志物纳米电化学分析检测研究;王晓英,理学博士,东南大学公共卫生学院副教授,硕士生导师.主要从事肿瘤相关标志物的生物传感与风险评估,食品安全、环境污染相关的纳米电化学分析检测研究.
  • 基金资助:

    项目受国家自然科学基金(Nos.81600179, 81302472)和江苏高校“青蓝工程”资助.

Progress in Analysis and Detection of Salivary Tumor Biomarkers Associated with Oral Cancer

Jin Xin, Wang XiaoYing   

  1. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
  • Received:2018-10-07 Published:2018-12-05
  • Contact: 10.6023/A18100414 E-mail:wxy@seu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81600179, 81302472) and “Blue Project” funded by universities in Jiangsu.

口腔癌系头颈部癌,癌组织均位于口腔内,其非侵入性早期诊断是减少该病死亡的有效手段.唾液系口腔癌变相关物质首先释放进入的体液,取材方便,安全无创,是口腔癌普查筛选、早期诊断的首选指标.本文对唾液肿瘤生物标志物的种类、目前国内外常用的检测方法进行概述,重点阐述新型电化学生物传感方法在口腔癌相关唾液肿瘤生物标志物检测方面的相关应用及其最新研究进展.并对口腔癌相关唾液肿瘤生物标志物电化学传感技术的未来发展方向提出展望,拟为其深入研究与应用提供参考.

关键词: 口腔癌, 唾液, 肿瘤生物标志物, 检测方法, 电化学生物传感器

Oral cancer is head and neck cancer, and cancer tissue is located in the oral cavity. The non-invasive early diagnosis is an effective method to reduce the death of the disease. The oral cancer-related substances are first released into the saliva, which is convenient, safe and non-invasive, and is the first choice for screening and early diagnosis of oral cancer. In this paper, the specific types and the commonly used detection methods of the salivary tumor biomarkers at home and abroad were summarized and compared. Specifically, the latest application of new electrochemical biosensor in the detection of the salivary tumor biomarkers associated with oral cancer was mainly described. Futhermore, the summary of its future directions and the potential applications was proposed, which provided reference for the further research and application of the salivary tumor biomarkers in oral cancer.

Key words: oral cancer, saliva, tumor biomarker, detection technology, electrochemical biosensor