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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (24): 2619-2621. 上一篇    

研究简报

离子液体[BMIm]BF4对莪术醇手性环氧异构体的拆分

郭平1,2，刘剑敏2，李校堃2，杨树林*,1，姚其正*,3   

  1. (1南京理工大学化工学院 南京 210094)
    (2温州医学院药学院 温州 325035)
    (3中国药科大学药学院 南京 210009)
  • 投稿日期:2010-06-24 修回日期:2010-08-16 发布日期:2010-08-30
  • 通讯作者: 姚其正 E-mail:qz_yao@yahoo.com.cn

Chiral Resolution of Curcumol Epoxy Derivatives by Ionic Liquid [BMIm]BF4

Guo Ping1,2 Liu Jianmin2 Li Xiaokun2 Yang Shulin*,1 Yao Qizheng*,3   

  1. (1 Institute of Chemical Technology, Nanjing University of Science and Technology, Nanjing 210094)
    (2 School of Pharmacy, Wenzhou Medical College, Wenzhou 325035)
    (3 School of Pharmacy, China Pharmaceutical University, Nanjing 210009)
  • Received:2010-06-24 Revised:2010-08-16 Published:2010-08-30

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利用莪术醇环氧手性异构体在离子液体1-丁基-3-甲基咪唑四氟硼酸盐中形成复合物的溶解度不同, 以22%的(10R)-10,14-环氧莪术醇(E1)收率(99% ee)和49%的(10S)-10,14-环氧莪术醇(E2)收率(92% ee)完成了对莪术醇环氧手性异构体的拆分. 离子液体可以回收利用, 回收后的离子液体分离效果不受影响.

关键词: 离子液体, 手性拆分, 莪术醇, 10,14-环氧莪术醇

The isomers of 10,14-epoxy curcumol derivatives were separated by the ionic liquid [BMIm]BF4, in which there is a difference in the solubility of the complexes formed with the isomers and [BMIm]BF4. The yield 22% of (10R)-10,14-epoxy curcumol (E1) with 99% ee and the yield 49% of (10S)-10,14-epoxy curcumol (E2) with 92% ee were obtained respectively in the resolution. The ionic liquid could be recovered easily and used again with the same separation effect.

Key words: ionic liquid, chiral resolution, curcumol, 10,14-epoxycurcumol