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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (02): 181-186. 上一篇    下一篇

研究论文

利用超分子接枝聚合物体系制备具有pH响应能力的高分子囊泡及其在药物控制释放方面的应用

李振泉1，钱健2，曹绪龙1，宋新旺1，吴飞鹏*,2   

  1. (1中国石化胜利油田分公司地质科学研究院 东营 257015)
    (2中国科学院理化技术研究所 光化学转换与功能材料重点实验室 北京 100190)
  • 投稿日期:2009-03-31 修回日期:2009-07-22 发布日期:2010-03-17
  • 通讯作者: 吴飞鹏 E-mail:fpwu@mail.ipc.ac.cn

pH-Sensitive Vesicles Prepared from Supramolecular Graft Copolymers and the Application in the Controlled Release of Drug

Li Zhenquan1 Qian Jian2 Cao Xulong1 Song Xinwang1 Wu Feipeng*,2   

  1. (1 Geological Research Institute of Shengli Oilfield Co. Ltd. SINOPEC, Dongying 257015)
    (2 Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190)
  • Received:2009-03-31 Revised:2009-07-22 Published:2010-03-17

PDF

1629

被引次数

20

利用自由基聚合的链转移反应, 制备了以羧基为端基的聚(N-异丙基丙烯酰胺)(PNIPAM-COOH), 然后以该聚合物作为亲水的侧链, 利用其羧端基和聚(4-乙烯基吡啶)(PVPy)疏水主链上的吡啶基团间的相互作用, 在共溶剂DMF中形成超分子两亲接枝聚合物体系, 在上述体系中逐滴加入水可以使其通过自组装形成高分子囊泡. 通过控制PVPy与PNIPAM-COOH的质量比在1～3之间, 可以控制囊泡尺寸在130～330 nm之间. 由于囊泡中含有吡啶基团, 因而该囊泡具有pH敏感性. 以日落黄为药物模型, 以这些pH敏感性囊泡作为药物载体, 通过调节环境的pH值可以实现对药物的控制释放.

关键词: 超分子作用, 自组装, 囊泡, 控制释放

Supramolecular graft copolymers (SGP) were prepared via the ionic interaction between poly(4-vinylpyridine) (PVPy) and poly(N-isopropylacrylamide) with carboxylic end groups (PNIPAM-COOH). Hydrophobic PVPy was used as main chains, and hydrophilic PNIPAM-COOH grafted onto the main chains through the ionic interaction between the carboxylic groups and pyridine groups. The SGP could self-assemble to form vesicles in DMF/H2O system. When modulating the mass ratio of PVPy to PNIPAM-COOH from 1 to 3, the size of the vesicles could be controlled from 130 to 330 nm. These vesicles were sensitive to pH, and could be deformed by changing pH. Drug-release studies showed that release rates of the loaded drug (sunset yellow) in the two vesicles could be controlled by the pH of the solution.

Key words: supramolecular interaction, self-assembly, vesicle, controlled release