化学学报 ›› 2012, Vol. 70 ›› Issue (09): 1088-1094.DOI: 10.6023/A1108232 上一篇    下一篇

研究论文

以马来松香丙烯酸乙二醇酯为交联剂的茶碱分子印迹膜电化学传感器的研究

谭学才a,b, 王琳b, 李鹏飞a, 龚琦b, 刘力a, 赵丹丹a, 雷福厚a, 黄在银a   

  1. a. 广西民族大学化学化工学院 广西林产化学与工程重点实验室 广西高校化学与生物转化过程重点实验室南宁 530008;
    b. 广西大学化学化工学院 南宁 530004
  • 投稿日期:2011-08-23 修回日期:2012-04-09 发布日期:2012-04-18
  • 通讯作者: 谭学才 E-mail:xctan@yahoo.cn
  • 基金资助:

    国家自然科学基金(Nos. 21065001, 30960306, 21165003)、广西自然科学基金(Nos. 0991084, 0991001z)、广西教育厅科研(Nos. 200812MS074)、广西林产化学品开发与应用重点实验室(No. GXFC08-06)资助项目.

Electrochemical Sensor for the Determination of Theophylline Based on Molecularly Imprinted Polymer with Ethylene Glycol Maleic Rosinate Acrylate as Cross-linker

Tan Xuecaia,b, Wang Linb, Li Pengfeia, Gong Qib, Liu Lia, Zhao Dandana, Lei Fuhoua, Huang Zaiyina   

  1. a. School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Chemical and Biological Transforming Process in Universities of Guangxi, Nanning 530008;
    b. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004
  • Received:2011-08-23 Revised:2012-04-09 Published:2012-04-18
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21065001, 30960306, 21165003), Guangxi Natural Science Foundation (Nos. 0991084, 0991001z), Scientific Reserch Fund of Guangxi Education Department (Nos. 200812MS074) and Guangxi Key Laboratory of Chemistry and Engineering of Forest Products (No. GXFC08-06).

利用分子印迹技术, 以马来松香丙烯酸乙二醇酯为交联剂, 丙烯酸为功能单体研制了测定茶碱的新型电化学传感器. 以自由基热聚合的方式于玻碳电极表面制备茶碱分子印迹聚合物膜. 通过循环伏安法、电化学交流阻抗法及计时电流法研究了传感器对茶碱的响应特性. 结果表明, 在最佳的实验条件下, 传感器的峰电流与茶碱浓度在2.00×10-7~3.45×10-4 mol/L 范围内呈现出良好的线性关系(线性相关系数为0.9961), 检出限(S/N=3)为1.00×10-7 mol/L;该传感器的选择性高, 稳定性和重现性好, 将此传感器用于茶碱缓释片中茶碱的含量测定, 回收率为95.6%~103.8%.关键词 马来松香丙烯酸乙二醇酯; 茶碱; 分子印迹聚合物; 电化学传感器

关键词: 马来松香丙烯酸乙二醇酯, 茶碱, 分子印迹聚合物, 电化学传感器

A novel electrochemical sensor for the determination of theophylline based on ethylene glycol maleic rosinate acrylate as the cross linking agent and acrylic acid as functional monomer was fabricated by molecularly imprinted technology. A molecularly imprinted polymers (MIPs) membrane was synthesized on the surface of a glassy carbon electrode in vacuum drying oven by free radical polymerization method. The electrochemical behavior of the membrane was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry. Under optimum conditions, it was found that the response of peak currents was linear to the concentration of theophylline in range of 2.00×10-7~3.45×10-4 mol/L (linear regression coefficient=0.9961) with the detection limit of 1.00×10-7 mol/L. The sensor not only has high selectivity, but also shows good stability and reproducibility. The sensor was applied to the determination of theophylline in theophylline sustained release tablets samples with recovery ranging from 95.6% to 103.8%.

Key words: ethylene glycol maleic rosinate acrylate, theophylline, molecularly imprinted polymer, electrochemical sensor