Acta Chimica Sinica ›› 2013, Vol. 71 ›› Issue (04): 493-500.DOI: 10.6023/A13010088 Previous Articles     Next Articles



吴金梅, 苏高星, 张斌, 闫兵   

  1. 山东大学化学与化工学院 济南 250100
  • 投稿日期:2013-01-17 发布日期:2013-03-01
  • 通讯作者: 闫兵
  • 基金资助:

    项目受国家重点基础研究发展计划(973计划)项目(No. 2010CB933504)和国家自然科学基金(Nos. 21137002, 21077068)资助.

Nanocombinatorial Chemistry in Nanomaterial Discovery and Nanomedicine

Wu Jinmei, Su Gaoxing, Zhang Bin, Yan Bing   

  1. School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100
  • Received:2013-01-17 Published:2013-03-01
  • Supported by:

    Project supported by the National Basic Research Program of China (973 Program, No. 2010CB933504) and the National Natural Science Foundation of China (Nos. 21137002, 21077068).

Combinatorial chemistry is a scientific technology covering computational chemistry, organic synthesis, and high-throughput screening. Combinatorial chemistry can achieve synthesis and screenings of large compounds within a short time, which can greatly improve compounds synthesis efficiency, shorten compounds discovery cycle and reduce cost effectively. It has greatly impacted on lead compounds discovery with high efficiency, miniaturization and high automation. In recent years, combinatorial chemistry was not only applied in drugs discovery, but also applied in catalyst discovery, pesticide discovery and polymer discovery because of its advantages. With the rapid development of nanotechnology, combinatorial chemistry strategies and high throughput technologies have been introduced to this area. The development of nanotechnology will have tremendous impacts on every aspect of our society. However, it requires a time-consuming research effort on the discovery and optimization of novel nanomaterials with unique properties. Parallel reactions and high-throughput screening are considered to be more efficient than conventional linear operations. In addition, combinatorial chemistry can achieve the biological activities variety of nanomaterials by modifying nanomaterials surface. In this review, we summarized the applications of nanocombinatorial chemistry in the discovery of novel nano materials and the discovery of medicines with modified nanomaterials. We also summarized many high-throughput screening technologies which were used in nanotechnology research, including magnetic resonance imaging (MRI), automation gene chip system and fluorescent activated cell sorter (FACS). Finally, for easily understanding the tendency of nano-combinatorial chemistry, some challenges and future perspectives of nanocombinatorial chemistry were also included.

Key words: combinatorial chemistry, high-throughput screening, nanomaterial, nanomedicine, nanocombinatorial chemistry