Acta Chimica Sinica ›› 2020, Vol. 78 ›› Issue (4): 289-298.DOI: 10.6023/A20020027 Previous Articles     Next Articles



廖港, 吴勇杰, 史炳锋   

  1. 浙江大学化学系 杭州 310027
  • 投稿日期:2020-02-08 发布日期:2020-03-12
  • 通讯作者: 史炳锋
  • 作者简介:廖港,博士后,2018年毕业于浙江大学,获理学博士学位,导师为史炳锋教授.同年在浙江大学化学系进行博士后研究工作.主要研究方向为过渡金属催化不对称碳氢键官能团化;吴勇杰,2017年在浙江科技学院获学士学位,现在在浙江大学史炳锋教授的指导下攻读博士学位.主要研究方向为过渡金属催化不对称碳氢键官能团化;史炳锋,博士,教授,独立课题组组长.2001年本科毕业于南开大学化学系,2006年博士毕业于中国科学院上海有机化学研究所,导师为俞飚研究员.2006~2007年在University of California,San Diego从事博士后研究,2007~2010年加入The Scripps Research Institute从事博士后研究,导师余金权教授.2010年4月加入浙江大学化学系,任独立课题组组长,博士生导师.独立工作以来,以通讯作者发表研究论文九十余篇,主要研究领域为过渡金属催化的惰性键活化及其在天然产物全合成中的应用.
  • 基金资助:

Noncovalent Interaction in Transition Metal-Catalyzed Selective C-H Activation

Liao Gang, Wu Yong-Jie, Shi Bing-Feng   

  1. Department of Chemistry, Zhejiang University, Hangzhou 310027
  • Received:2020-02-08 Published:2020-03-12
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21901228, 21772170), the China Postdoctoral Science Foundation (No. 2019M650135), the Outstanding Young Talents of Zhejiang Province High-level Personnel of Special Support (No. ZJWR0108) and the Natural Science Foundation of Zhejiang Province (No. LR17B020001).

Transition metal-catalyzed direct C-H functionalization is one of the most efficient and powerful tools for the rapid synthesis of organic molecules. The use of functional groups in the molecules or covalently attached coordinating groups as directing groups has been realized as a major strategy to control the selectivity. Noncovalent interactions are of great importance in the field of molecular biology, supramolecular chemistry, material science and drug discovery. More recently, the use of well-designed ligands to enable the site-selective C-H functionalization via noncovalent interactions has emerged as a highly promising yet relatively less explored strategy. In this perspective, recent advances in this cutting-edge area are summarized. The perspective was classified into four sections according to the type of noncovalent interactions, including hydrogen bonding, ion pair, Lewis acid-base interaction and electrostatic interaction. Emphasis is placed on the mode of noncovalent interactions among the transition metals, ligands and substrates. The limitation of current research and the prospect of future work will also be discussed. We anticipate that this strategy might become a promising complementary strategy to control the positional selectivity in C-H functionalization reactions.

Key words: noncovalent interaction, selectivity, C—H activation, transient directing group