Acta Chimica Sinica ›› 2002, Vol. 60 ›› Issue (2): 355-359. Previous Articles     Next Articles

Original Articles

氨基甲酸酯型脱氧胆酸分子钳对氨基酸甲酯的手性识别 研究

薛翠花;牟其明;陈淑华   

  1. 四川大学化学学院.成都(610064)
  • 出版日期:2002-02-15 发布日期:2002-02-15

Enantioselective recognition of carbamate-type molecular tweezers derived from deoxycholic acid for amino acid methyl esters

Xue Cuihua;Mu Qiming;Chen Shuhua   

  1. Sichuan Univ, Coll Chem.Chengdu(610064)
  • Online:2002-02-15 Published:2002-02-15

New chiral molecular tweezers 1~4 have been synthesized by using deoxycholic acid as a spacer to bridge the different aromatic amines. Their structures were confirmed by IR, ^1H NMR and elemental analysis. Enantioselective recognition properties of these molecular tweezers for amino acid methyl esters have been investigated by UV-vis spectra titration in CHCl3 at 25℃. The results indicate that molecular tweezers 1~4 not only recognize all amino acid methyl esters examined but also possess higher selectivity for D-amino acid methyl esters. The recognition ability and selectivity are discussed from the viewpoint of the size/shape-fit and geometrical complementary relationship between the molecular tweezers and amino acid methyl esters.

Key words: CARBAMIC ACID ESTER, DEOXYCHOLIC ACID, ENANTIOMORPH, SELECTIVITY, AMINO ACID, OLECULAR RECOGNITION

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