Molecular Mechanics Study on the Recognition and Partial Structural Repair of Cyclobutane Pyrimidine Dimer Including Double G:T Mis-matched Pairs by the Chiral Metal Complex Δ,Λ-[Ru(IP)2dppz]2＋

Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (2): 116-122. Previous Articles Next Articles

Original Articles

手性金属配合物Δ,Λ-[Ru(IP)₂dppz]^2＋对含G:T错配的环丁烷嘧啶二聚体识别和部分构型修复的分子力学研究

常永龙, 张翠萍, 杨频*

(山西大学分子科学研究所化学生物学与分子工程教育部重点实验室太原 030006)

投稿日期:2006-04-26 修回日期:2006-08-02 发布日期:2007-01-28
通讯作者: 杨频

Molecular Mechanics Study on the Recognition and Partial Structural Repair of Cyclobutane Pyrimidine Dimer Including Double G:T Mis-matched Pairs by the Chiral Metal Complex Δ,Λ-[Ru(IP)₂dppz]^2＋

CHANG Yong-Long; ZHANG Cui-Ping; YANG Pin*

(Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006)

Received:2006-04-26 Revised:2006-08-02 Published:2007-01-28
Contact: YANG Pin

Abstract

The cyclobutane pyrimidine dimer (CPD) is the chief tache when ultraviolet ray damages DNA that could lead to skin cancer. XPC-hHR23B complex was used as the initial recognition complex of CPD. But its recognition efficiency was very low. This article firstly studied on the recognition of the chiral metal complex Δ,Λ-[Ru(IP)₂dppz]^2＋ to CPD double helix DNA including double G:T mismatched pairs by molecular modeling. The results revealed that both of two isomers of [Ru(IP)₂dppz]^2＋could recognize CPD and the interaction was enantioselective, grooveselective and sitespecific. We also found that the shape of two T bases forming CPD changed from mouth shape to approximate parallel shape after Λ-[Ru(IP)₂dppz]^2＋intercalating DNA. That was the initial conformational repair.

Key words: metal complex, cyclobutane pyrimidine dimer (CPD), molecular modeling, setric hindrance, electrostatic interaction

Cite this article

CHANG Yong-Long; ZHANG Cui-Ping; YANG Pin* . Molecular Mechanics Study on the Recognition and Partial Structural Repair of Cyclobutane Pyrimidine Dimer Including Double G:T Mis-matched Pairs by the Chiral Metal Complex Δ,Λ-[Ru(IP)₂dppz]^2＋[J]. Acta Chimica Sinica, 2007, 65(2): 116-122.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Xuelu Ma, Meng Li, Ming Lei. Trinuclear Transition Metal Complexes in Catalytic Reactions [J]. Acta Chimica Sinica, 2023, 81(1): 84-99.
[2]	Shimin Zhu, Xin Huang, Xie Han, Simin Liu. Recognition and Luminescence Properties of N^C^N Pt(II) Complexes with Macrocyclic Host Cucurbit[10]uril [J]. Acta Chimica Sinica, 2022, 80(8): 1066-1070.
[3]	Li Wei, Ran Tiecheng, Zhang Yu, He Wei, Ma Jifei, Wang Qisheng, Zhang Jichao, Zhu Ying. SiO₂-Mediated High-efficiency Enrichment of 5 nm Gold Nanoparticles and Their Catalytic Activity [J]. Acta Chimica Sinica, 2020, 78(2): 170-176.
[4]	Yan Lin, Ren Yongshuo, Wang Xuejing, Mu Wei, Han Xiaojun. Coacervate and Its Application in the Field of Artificial Cells [J]. Acta Chimica Sinica, 2020, 78(11): 1150-1163.
[5]	Ma Yun, Chen Kexin, Guo Zeling, Liu Shujuan, Zhao Qiang, Wong Wai-Yeung. Phosphorescent Soft Salt Complexes for Optoelectronic Applications [J]. Acta Chimica Sinica, 2020, 78(1): 23-33.
[6]	Cui Bin-Bin, Tang Jian-Hong, Zhong Yu-Wu. Resistive Memory Materials Based on Transition-Metal Complexes [J]. Acta Chim. Sinica, 2016, 74(9): 726-733.
[7]	Zhang Yiwe, Ma Xuelu, Zhang Xin, Lei Ming. Theoretical Study on N-N Activation by Thiolate-bridged Dinuclear Dinitrogen Transition-metal Complexes [J]. Acta Chim. Sinica, 2016, 74(4): 340-350.
[8]	Wu Xiang, Li Mingli, Gong Liuzhu. Asymmetric Relay Catalysis Reaction Consisting of Metal Complex and Chiral Phosphoric Acids [J]. Acta Chimica Sinica, 2013, 71(08): 1091-1100.
[9]	Qiu Yixiang, Wang Shuguang. Theoretical Investigations on Tris(pentamethylcyclopentadienyl) Rare Earth Metal Complexes (C₅Me₅)₃Ln (Ln=Sc, Y, La) [J]. Acta Chimica Sinica, 2012, 70(18): 1930-1938.
[10]	Wang Xinke, Sit Met-Met, Sun Jiea, Tang Yong, Xie Zuowei. Synthesis, Structure and Ethylene Polymerization Behavior of Group 4 Metal Complexes Bearing Salicylaldaminato Ligands with Appended Donor Functionality [J]. Acta Chimica Sinica, 2012, 70(18): 1909-1916.
[11]	Zhang Yun, Xi Xiaoqing, Xu Shanni, Zhou Junchen, Zhou Jinjin, Xu Qihong, Shen Haoyu. Adsorption Studies on Phosphate by Amino-functionalized Nano-size Composite Materials [J]. Acta Chimica Sinica, 2012, 70(17): 1839-1846.
[12]	Zheng Ke, Lin Lili, Feng Xiaoming. Chiral N,N '-Dioxide-Ni(II) Complex Catalyzed Asymmetric Carbonyl-Ene Reaction of Ethyl Trifluoropyruvate [J]. Acta Chimica Sinica, 2012, 70(17): 1785-1790.
[13]	Jiang Yong, Qiu Xiao, Li Xia. Fluorinated Dicarboxylic Acids and Transition-metal(Ⅱ) Complexes with N-ligands: Synthesis, Characterizations and Crystal Structures [J]. Acta Chimica Sinica, 2012, 70(03): 303-310.
[14]	Li Yue, Gu Yu, He Jia, He Hu, Zhou Yi, Chuong Pham-Huy. Study on Interaction between Myricetin and Bovine Serum Albumin by Spectroscopy and Molecular Modeling [J]. Acta Chimica Sinica, 2012, 70(02): 143-150.
[15]	LIU Lu-Sha, FAN Jun, HU Chun-Mei, SUN Yang, HU Xiao-Yun, ZHAO Ying-Yong, WEI Song, LIANG Xu-Hua. Studies on the Interaction between TubeimosideII and Human Serum Albumin by Spectroscopic Methods [J]. Acta Chimica Sinica, 2011, 69(21): 2589-2596.

手性金属配合物Δ,Λ-[Ru(IP)₂dppz]^2＋对含G:T错配的环丁烷嘧啶二聚体识别和部分构型修复的分子力学研究

Molecular Mechanics Study on the Recognition and Partial Structural Repair of Cyclobutane Pyrimidine Dimer Including Double G:T Mis-matched Pairs by the Chiral Metal Complex Δ,Λ-[Ru(IP)₂dppz]^2＋

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

手性金属配合物Δ,Λ-[Ru(IP)2dppz]2＋对含G:T错配的环丁烷嘧啶二聚体识别和部分构型修复的分子力学研究