Acta Chimica Sinica ›› 2020, Vol. 78 ›› Issue (7): 613-624.DOI: 10.6023/A20040126 Previous Articles     Next Articles



齐野a,b, 任双颂c, 车颖c, 叶俊伟a,b, 宁桂玲a,b   

  1. a 大连理工大学化工学院 精细化工国家重点实验室 大连 116024;
    b 辽宁省硼镁特种功能材料制备与应用技术工程实验室 大连 116024;
    c 大连医科大学附属第一医院 大连 116011
  • 投稿日期:2020-04-28 发布日期:2020-05-30
  • 通讯作者: 叶俊伟, 宁桂玲;
  • 作者简介:齐野,博士研究生,2017年毕业于大连海事大学,获理学硕士学位.2017年起于大连理工大学化工学院攻读博士学位.主要研究方向为含硼金属有机框架复合材料的结构构筑及其在抗菌、抗癌等生物领域上的应用.
  • 基金资助:

Research Progress of Metal-Organic Frameworks Based Antibacterial Materials

Qi Yea,b, Ren Shuangsongc, Che Yingc, Ye Junweia,b, Ning Guilinga,b   

  1. a State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024;
    b Engineering Laboratory of Boric and Magnesic Functional Material Preparative and Applied Technology in Liaoning Province, Dalian 116024;
    c The First Affiliated Hospital of Dalian Medical University, Dalian 116011
  • Received:2020-04-28 Published:2020-05-30
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. U1808210, U1607101) and the Fundamental Research Funds for the Central Universities (No. DUT20LK37).

With the accelerating process of industrialization and urbanization, as well as the increasing proportion of the elderly in the world's population, we are facing more complex health threats related to bacterial infection. While the vast majority of the bacteria in the body are rendered harmless by the protective effects of the immune system, the continued abuse and misuse of antibiotics has accelerated the spread of antibiotic-resistant bacterial strains and has resulted in substantial new challenges with respect to modern-day antibiotic-based treatments. Therefore, intelligent design of new antibacterial modalities to be used for treating human and livestock diseases is an extremely urgent priority for researchers in the fields of chemistry, chemical engineering, materials and biomedical sciences. Toward this end, the most intriguing of the new developments are metal-organic frameworks (MOFs). MOFs are versatile crystalline porous lattices of organic ligands and metal ion/clusters that formed by self-assembly via coordination bonds. Due to their unique characteristics, including relatively straight forward and simple methods for synthesis, large surface areas, novel and diverse structures, and adjustable porosity, MOFs not only play strong roles with respect to novel methods for gas storage and separation, they may also be utilized in unique applications associated with sensors mechanisms and catalysis. These features contribute to our current understanding of MOFs as promising candidates for the development of pharmaceutical and specifically antibacterial applications. In this review, antibacterial mechanisms, and the development of resistance to current antibiotic strategies are summarized and discussed. The main mechanisms by which bacteria show resistance to antibiotics include altered metabolic pathways, regulation of target sites, and inactivation, modification, and/or reduction in the capacity to accumulate antibacterial drugs. We consider recent progress on the development of MOFs, including the use of specific metal centers and ligands, metal nanoparticles, and drug-encapsulation, all of which have important applications with respect to antibacterial activities, and wound healing. Finally, the challenges and prospects of MOF-based antibacterial materials are discussed, including critical findings, which will help toward the development of the next generation antibacterial MOFs for human use.

Key words: metal-organic framework, antibacterial, mechanism, reactive oxygen species, drug delivery