有机化学 ›› 2013, Vol. 33 ›› Issue (08): 1686-1696.DOI: 10.6023/cjoc201212048 上一篇    下一篇

综述与进展

水解酶的非专一性催化在有机合成中的应用

葛新a, 赖依峰a,b, 陈新志a   

  1. a 浙江大学生物质化工教育部重点实验室 杭州 310027;
    b 浙江科技学院生物与化学工程学院 杭州 310012
  • 收稿日期:2013-01-04 修回日期:2013-02-04 发布日期:2013-02-18
  • 通讯作者: 陈新志 E-mail:xzchen@zju.edu.cn
  • 基金资助:

    浙江省重点科技创新团队(No. 2009R50002)资助项目.

Application of Hydrolase Catalytic Promiscuity in Organic Synthesis

Ge Xina, Lai Yifenga,b, Chen Xinzhia   

  1. a Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027;
    b Zhejiang University of Science and Technology, School of Biological and Chemical Engineering, Hangzhou 310012
  • Received:2013-01-04 Revised:2013-02-04 Published:2013-02-18
  • Supported by:

    Project supported by the Key Innovation Group of Zhejiang Province (No. 2009R50002).

介绍了水解酶非专一性催化的机理, 对水解酶的非专一性催化在单元、两步和一锅三组分的有机反应中, 特别是加成反应、Aldol反应和Knoevenagel反应中的研究与应用进行了总结和概述.

关键词: 水解酶, 非专一性, Michael 加成, Aldol反应, 一锅三组分

This review introduces the mechanism of hydrolase promiscuity. Several applications of hydrolase catalytic promiscuity in unit reaction, two-step reaction and three-component reaction are summarized, especially for addition, aldol reaction, and Knoevenagel reaction.

Key words: hydrolase, promiscuity, Michael addition, aldol reaction, three-component reaction