有机化学 ›› 2016, Vol. 36 ›› Issue (3): 622-625.DOI: 10.6023/cjoc201509033 上一篇    下一篇

研究论文

一种新型1,3,4-噁二嗪酮化合物的合成及其晶体结构

孙宏顺a,b, 王建强a, 谭文文b, 杨海东b, 李玉龙b, 沈临江a, 郭成a   

  1. a 南京工业大学化学与分子工程学院 南京 211816;
    b 南京科技职业学院化学工程系 南京 210048
  • 收稿日期:2015-09-25 修回日期:2015-10-27 出版日期:2016-03-25 发布日期:2015-11-06
  • 通讯作者: 沈临江 E-mail:ljshen@njut.edu.cn
  • 基金资助:

    国家自然科学青年基金(No. 21106069)、南京科技职业学院院级重点(No. NHKY-2015-1)资助项目.

Synthesis and Crystal Structure of a Novel 1,3,4-Oxadiazin-one Compound

Sun Hongshuna,b, Wang Jianqianga, Tan Wenwenb, Yang Haidongb, Li Yulongb, Shen Linjianga, Guo Chenga   

  1. a College of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816;
    b Department of Chemical Engineering, Nanjing Polytechnic Institute, Nanjing 210048
  • Received:2015-09-25 Revised:2015-10-27 Online:2016-03-25 Published:2015-11-06
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21106069) and the Key Program of Nanjing Polytechnic Institute (No. NHKY-2015-1).

以苯并噻吩-2-甲酸为原料, 经酯化、肼解、肼的酰基化和环化四步反应合成了一种新型化合物2-(2-苯并噻吩基)-4H-1,3,4-噁二嗪-5(6H)-酮(4). 产物结构经1H NMR, 13C NMR, ESI-MS, FT-IR, 元素分析及X单晶衍射表征.

关键词: 苯并噻吩, 噁二嗪, 合成, 晶体结构

Using benzothiophene-2-carboxylic acid as a raw material, 2-(1-benzothiophen-2-yl)-4H-1,3,4-oxadiazin-5(6H)-one (4) was synthesized by esterification and hydrazinolysis, followed by the acylation and cyclization reactions. The novel compound 4 was characterized by 1H NMR, 13C NMR, ESI-MS, FT-IR, elemental analysis and X-ray single crystal diffraction.

Key words: benzothiophen, oxadiazin, synthesis, crystal structure