有机化学 ›› 2018, Vol. 38 ›› Issue (2): 341-349.DOI: 10.6023/cjoc201708040 上一篇    下一篇

综述与进展

手性诱导构建磷手性中心不对称合成有机磷功能化合物研究进展

刘双a, 李玉明a, 王典a, 魏榕a, 苗志伟a,b   

  1. a 南开大学化学学院 元素有机化学国家重点实验室 天津 300071;
    b 清华大学 生命有机磷化学及化学生物学教育部重点实验室 北京 100084
  • 收稿日期:2017-08-20 修回日期:2017-09-24 出版日期:2018-02-25 发布日期:2017-10-16
  • 通讯作者: 苗志伟 E-mail:miaozhiwei@nankai.edu.cn
  • 基金资助:

    国家重点研发计划(No.2016YFD0201200)资助项目.

Research Progress of Asymmetric Synthesis of Optically Active P-Stereogenic Organophosphoryl Compounds by Chiral Induction

Liu Shuanga, Li Yuminga, Wang Diana, Wei Ronga, Miao Zhiweia,b   

  1. a State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071;
    b Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education, Tsinghua University, Beijing 100084
  • Received:2017-08-20 Revised:2017-09-24 Online:2018-02-25 Published:2017-10-16
  • Contact: 10.6023/cjoc201708040 E-mail:miaozhiwei@nankai.edu.cn
  • Supported by:

    Project supported by the National Key Research and Development Program of China (No. 2016YFD0201200).

有机磷化学是有机化学和生命科学研究的重要分支,具有磷手性中心的有机磷化合物在医药、农药、材料和不对称合成等研究领域中具有广泛的应用.利用自然界广泛存在的天然手性化合物作为手性诱导试剂,通过相应的化学转化可以高效合成具有光学活性的磷手性有机磷功能化合物.综述了近年来利用薄荷醇、金雀花碱、麻黄碱和碳水化合物等天然产物作为手性诱导试剂,不对称合成磷手性有机磷功能化合物的研究进展.

关键词: 磷手性有机磷化合物, 手性诱导, 不对称合成

Organo-phosphorus chemistry is an important branch of organic chemistry and life science research. P-Stereogenic organophosphorus compounds have attracted great interest due to their potential applications in the fields of pharmaceutical chemistry, agrochemistry, material science and as ligands for asymmetric catalysis. The preparation of enantiomerically enriched phosphorus compounds with P-stereogenic centers using natural chiral compounds as chiral auxiliary has received considerable attention. The recent development of the asymmetric synthesis of P-stereogenic organophosphoryl compounds employing menthol, sparteine, ephedrine, and carbohydrates as chiral auxiliary is summarized.

Key words: P-stereogenic organophosphorus compound, chiral induction, asymmetric synthesis