有机化学 ›› 2019, Vol. 39 ›› Issue (2): 521-526.DOI: 10.6023/cjoc201805052 上一篇    下一篇

研究简报

聚乙二醇接枝4-二甲氨基吡啶功能化离子液体催化合成吡唑并[1,2-b]酞嗪-5,10-二酮

王英磊a, 万子娟b, 罗军b   

  1. a 南阳理工学院生物与化学工程学院 南阳 473004;
    b 南京理工大学化工学院 南京 210094
  • 收稿日期:2018-05-29 修回日期:2018-07-09 出版日期:2019-02-25 发布日期:2018-10-20
  • 通讯作者: 王英磊 E-mail:wangyinglei2014@163.com
  • 基金资助:

    国家自然科学基金(No.21002050)、河南省科技攻关项目(No.182102310601)、河南省高等学校重点科研(No.17B150007)资助项目.

Synthesis of Pyrazolo[1,2-b]phthalazine-5,10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid

Wang Yingleia, Wan Zijuanb, Luo Junb   

  1. a School of Biological and Chemical Engineering, Nanyang Institute of Technology, Nanyang 473004;
    b School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094
  • Received:2018-05-29 Revised:2018-07-09 Online:2019-02-25 Published:2018-10-20
  • Contact: 10.6023/cjoc201805052 E-mail:wangyinglei2014@163.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21002050) the Key Project of Science and Technology of Henan Province (No. 182102310601) and the Key Scientific Research Projects of Henan Province (No. 17B150007).

制备了一种聚乙二醇接枝4-二甲氨基吡啶功能化离子液体([DMAP-PEG1000-DIL][BF4]),采用1H NMR、13C NMR、FT-IR、ESI-MS对其进行结构表征.在[DMAP-PEG1000-DIL][BF4]催化下,具有不同取代基的芳香醛均可与丙二腈(或氰乙酸乙酯)、邻苯二甲酰肼在水介质中顺利反应,以85%~96%的产率合成了一系列吡唑并[1,2-b]酞嗪-5,10-二酮化合物.该方法具有反应条件温和,离子液体稳定性高且可回收利用,对环境友好等优点.

关键词: 聚乙二醇, 离子液体, 4-二甲氨基吡啶, 吡唑并[1,2-b]酞嗪-5,10-二酮, 水介质

A novel poly(ethylene glycol) grafted 4-dimethylaminopyridine functionalized ionic liquid ([DMAP-PEG1000-DIL] [BF4]) was prepared and characterized by 1H NMR, 13C NMR, FT-IR and ESI-MS. In the presence of[DMAP-PEG1000-DIL] [BF4], various substituted aromatic aldehyde could react with malononitrile (or ethyl cyanoacetate) and phthalhydrazide in water to obtain a series of pyrazolo[1,2-b]phthalazine-5,10-dione derivatives with 85%~96% yields. The mild reaction conditions, high stable and recyclable ionic liquids, environmental friendliness are advantages of this methodology.

Key words: poly(ethylene glycol), ionic liquid, 4-dimethylaminopyridine, pyrazolo[1,2-b]phthalazine-5,10-dione, aqueous media