有机化学 ›› 2019, Vol. 39 ›› Issue (2): 561-565.DOI: 10.6023/cjoc201807041 上一篇    下一篇

研究简报

7,4'-二甲氧基洋芹素-5-O-葡萄糖苷的高效合成

颜世强, 李英霞   

  1. 复旦大学药学院 上海 201203
  • 收稿日期:2018-07-23 修回日期:2018-08-25 发布日期:2018-09-10
  • 通讯作者: 李英霞 E-mail:liyx417@fudan.edu.cn
  • 基金资助:

    国家自然科学基金(No.81773576)资助项目.

Efficient Synthesis of 7,4'-Dimethylapigenin-5-O-glycoside

Yan Shiqiang, Li Yingxia   

  1. School of Pharmacy, Fudan University, Shanghai 201203
  • Received:2018-07-23 Revised:2018-08-25 Published:2018-09-10
  • Contact: 10.6023/cjoc201807041 E-mail:liyx417@fudan.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81773576).

7,4'-二甲氧基洋芹素-5-O-葡萄糖苷作为珍贵中药白木香的有效成分具有抑制LPS诱导巨噬细胞生成NO活性.由于5-位羟基具有较强的分子内氢键,5-位氧苷的黄酮类化合物在传统的糖苷化条件不能高效合成.以价廉易得的柚皮素和D-葡萄糖为原料,经选择性羟基保护、硼氢化钠还原、相转移催化下的糖苷化、2,3-二氯-5,6-二氰基对苯醌(DDQ)氧化等6步反应,以36.0%的总收率完成了7,4'-二甲氧基洋芹素-5-O-葡萄糖苷的化学合成,为该化合物进一步的生物活性研究奠定了物质基础.

关键词: 白木香, 7,4'-二甲氧基洋芹素-5-O-葡萄糖苷, 黄酮, 化学合成

As the active component of precious Chinese medicine Aquilaria sinensis, 7,4'-dimethylapigenin-5-O-glycoside showed inhibitory activity for nitric oxide (NO) production by activated RAW 264.7 cells. Because of the strong intramolecular H-bond, the 5-O-glucosidic linkage in flavonoids could not be efficiently constructed via conventional glycosylation method. In this paper, the efficient chemical synthesis of 7,4'-dimethylapigenin-5-O-glycoside has been achieved for the first time starting from commercially available naringenin and D-glucose via a linear reaction sequence of 6 steps with the overall yield of 36.0%, wherein selective hydroxy protecting, reduction with sodium borohydride, glycosylation under phase transfer catalytic condition, oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and other reactions were used. This work definitely laid the foundation for the further pharmacological study of this natural compound.

Key words: Aquilaria sinensis, 7,4'-dimethylapigenin-5-O-glycoside, flavonoids, chemical synthesis