有机化学 ›› 2019, Vol. 39 ›› Issue (4): 982-1012.DOI: 10.6023/cjoc201810006 上一篇    下一篇

综述与进展

2006~2018年稀有放线菌中的新天然产物

张举成a,b, 杨雪琼b, 周皓b, 杨亚滨b, 丁中涛b   

  1. a 红河学院理学院/云南省高校天然药物与化学生物学重点实验室 蒙自 661199;
    b 云南大学化学科学与工程学院 昆明 650091
  • 收稿日期:2018-10-07 修回日期:2018-12-18 出版日期:2019-04-25 发布日期:2019-01-10
  • 通讯作者: 杨亚滨, 丁中涛 E-mail:ybyang@ynu.edu.cn;ztding@ynu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21362010,81560571,81660582)、云南省地方本科高校(部分)基础研究联合基金重点项目(No.2017FH001-003)、云南省高等学校科技创新团队支持计划资助项目.

New Natural Products of Rare Actinomycetes from 2006 to 2018

Zhang Juchengaa,b, Yang Xueqiongb, Zhou Haob, Yang Yabinb, Ding Zhongtaob   

  1. a Key Laboratory of Natural Pharmaceutical & Chemical Biology of Yunnan Province/School of Science, Honghe University, Mengzi 661199;
    b School of Chemical and Technology, Yunnan University, Kunming 650091
  • Received:2018-10-07 Revised:2018-12-18 Online:2019-04-25 Published:2019-01-10
  • Contact: 10.6023/cjoc201810006 E-mail:ybyang@ynu.edu.cn;ztding@ynu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21362010,81560571,81660582),the Key Project of Yunnan Local Colleges Applied Basic Research Project (No.2017FH001-003),and the Innovative Research Team (in Science and Technology) in University of Yunnan Province.

微生物作为药物先导化合物的主要来源,在药物开发中具有重要的研究价值.从放线菌中发现了大量的活性新化合物,其中从稀有放线菌中得到的新化合物的数量呈现上升态势.对2006年1月~2018年6月报道的从陆地植物、土壤、海洋沉积物、海洋动物等来源的稀有放线菌中所发现的新活性化合物进行综述,结构类型涉及大环内酯、聚酮、蒽醌、联吡啶类、多烯等类型化合物,包括515个新天然产物.同时对稀有放线菌的生物转化也进行了综述.

关键词: 稀有放线菌, 活性化合物, 来源, 结构, 生物转化

The microbe is an important source of lead compound. It plays an important role in drug development. Many new active compounds were found from actinomycetes, and the number of new compounds from rare actinomycetes showed an upward trend. This paper introduces the new active compounds including 515 new natural products found in rare actinomycetes, from plants, soil, marine sediment, marine animals and so on. The structure type included macrolides, polyketides, anthraquinones, bipyridines, polyene, etc. The biotransformation of natural products by rare actinomycetes was reported from January 2006 to June 2018.

Key words: rare actinomycetes, activity compounds, source, structure, biotransformation