有机化学 ›› 2019, Vol. 39 ›› Issue (9): 2632-2638.DOI: 10.6023/cjoc201901037 上一篇    下一篇

研究论文

碱性蛋白酶催化合成喹唑啉酮衍生物

谢宗波, 李红霞, 刘联胜, 兰金, 胡智宇, 乐长高   

  1. 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2019-01-24 修回日期:2019-03-27 出版日期:2019-09-25 发布日期:2019-04-11
  • 通讯作者: 谢宗波, 乐长高 E-mail:zbxie@ecit.cn;zhgle@ecit.cn
  • 基金资助:

    国家自然科学基金(Nos.21462001,21465002,21262002)、江西省科技计划(No.20161BCB24006)、江西省教育厅科技(Nos.KJLD14050,GJJ150584)资助项目.

Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease

Xie Zongbo, Li Hongxia, Liu Liansheng, Lan Jin, Hu Zhiyu, Le Zhanggao   

  1. Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2019-01-24 Revised:2019-03-27 Online:2019-09-25 Published:2019-04-11
  • Contact: 10.6023/cjoc201901037 E-mail:zbxie@ecit.cn;zhgle@ecit.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21465002, 21262002), the Science and Technology Projects of Jiangxi (No. 20161BCB24006), and the Science and Technology Foundation of the Jiangxi Education Department (Nos. KJLD14050, GJJ150584).

以碱性蛋白酶为生物催化剂,通过二羰基化合物和邻氨基苯甲酰胺间的缩合反应合成了喹唑啉酮类衍生物.乙醇作为环保型溶剂,可以减少反应对环境的影响.碱性蛋白酶具有催化活性高,环保,来源广泛,操作简单等优点.本方法仅使用2000 U碱性蛋白酶作为催化剂,即可获得各种喹唑啉酮衍生物,且具有良好至优异的产率.

关键词: 喹唑啉酮衍生物, 生物催化, 碱性蛋白酶, 乙醇, 非专一性

Alkaline protease-catalyzed synthesis of quinazolinone derivatives was developed between β-keotester and o-aminobenzamide. Because ethanol is one kind of eco-friendly solvents, this method can reduce the impact of solvents on the environment. Alkaline protease as a biocatalyst has many advantages, e.g. high catalytic activity, environmentally friendly, wide variety of sources and simple operation. In addition, a variety of quinazolinone derivatives was obtained with good to excellent yields just using 2000 U alkaline protease as catalyst.

Key words: quinazolinone derivatives, biocatalysis, alkaline protease, ethanol, promiscuity