有机化学 ›› 2020, Vol. 40 ›› Issue (8): 2185-2194.DOI: 10.6023/cjoc202005017 上一篇    下一篇

研究专题

路易斯碱-硼自由基在硼化反应、自由基催化和还原反应中的应用

靳继康, 夏慧敏, 张凤莲, 汪义丰   

  1. 中国科学技术大学化学系 合肥 230026
  • 收稿日期:2020-05-07 修回日期:2020-05-19 出版日期:2020-08-25 发布日期:2020-05-29
  • 通讯作者: 汪义丰 E-mail:yfwangzj@ustc.edu.cn
  • 基金资助:
    国家自然科学基金(Nos.21672195,21702201,21971226)和中央高校基本科研业务费专项资金(No.WK2060190082)资助项目.

Lewis-Base Boryl Radicals Enabled Borylation, Radical Catalysis and Reduction Reactions

Jin Jikang, Xia Huimin, Zhang Fenglian, Wang Yifeng   

  1. Department of Chemistry, University of Science and Technology of China, Hefei 230026
  • Received:2020-05-07 Revised:2020-05-19 Online:2020-08-25 Published:2020-05-29
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21672195, 21702201, 21971226) and the Fundamental Research Funds for the Central Universities (No. WK2060190082).

自由基反应具有高效迅捷、选择性优良及官能团容忍性好等优点,是构建有机化合物的有效策略和方式之一.路易斯碱-硼自由基具有独特的结构和反应性能,在有机合成中表现出了良好的应用潜力.总结了我们课题组在路易斯碱-硼自由基促进的有机分子转化方面取得的一些进展.研究成果主要包括以下三个方面:路易斯碱-硼自由基促进的硼化反应、路易斯碱-硼自由基催化反应,以及路易斯碱-硼自由基引发的还原反应.这些反应具有条件温和,官能团容忍性好,产率高,化学、区域选择性好等优点.

关键词: 路易斯碱-硼自由基, 自由基硼化反应, 自由基催化反应, 自由基还原反应, 自由基化学

Free radical reactions represent an efficient and significant tool to construct organic molecules by taking advantages of the high-efficiency, remarkable selectivity and good functional groups tolerance. Lewis-base boryl radicals are a class of species that possess unique structures and chemical reactivity, and a variety of synthetic applications have been developed. This account summarizes the research advances in this research field mainly contributed by our group. The results include Lewis-based boryl radicals enabled borylation reactions, Lewis-based boryl radicals-catalyzed new reactions, and Lewis-based boryl radicals promoted reduction reactions. These reactions feature mild reaction conditions, good functional groups compatibility, high yields, and excellent chemo-, regio-, and stereo-selectivities.

Key words: Lewis-base boryl radicals, radical borylation reactions, radical catalysis, radical reduction reactions, free radical chemistry