有机化学 ›› 2005, Vol. 25 ›› Issue (03): 254-263. 上一篇    下一篇

综述与进展

肽核酸的合成、修饰和应用

褚征,刘克良*   

  1. (军事医学科学院毒物药物研究所 北京 100850)
  • 收稿日期:2003-10-14 修回日期:2004-07-14 发布日期:2005-02-28
  • 通讯作者: 刘克良

Peptide Nucleic Acid (PNA): Synthesis, Modifications andApplications

CHU Zheng, LIU Ke-Liang*   

  1. (Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850)
  • Received:2003-10-14 Revised:2004-07-14 Published:2005-02-28
  • Contact: LIU Ke-Liang

肽核酸是寡核苷酸模拟物, 它的糖-磷酸骨架被N-(2-氨基乙基)甘氨酸骨架所代替. 为了优化肽核酸的性质, 各种结构的肽核酸(PNA)单体被合成出来. 综述了肽核酸的合成、结构修饰及应用.

关键词: 肽核酸, 合成, 应用, 修饰

Peptide nucleic acid (PNA) is DNA mimic, in which the sugar-phosphate backbone is replaced by a N-(2-aminoethyl)glycine polyamide structure. For optimizing the characteristics, various PNA monomers had been synthesized. The synthesis, modifications and applications of PNA are reviewed.

Key words: PNA, modification, application, synthesis