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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (03): 360-363. 上一篇    下一篇

研究简报

N-(2-羧基-1,3,4-噻二唑-5-基)-N'-芳酰基硫脲与芳氧乙酰基硫脲的合成与生物活性

龚银香1,3，王子云2，张正文3，陈传兵3，汪焱钢*,3   

  1. (1长江大学化学与环境工程学院 荆州 434000)
    (2周口师范学院化学系 周口 466000)
    (3华中师范大学化学学院 武汉 430079)
  • 收稿日期:2005-04-06 修回日期:2005-09-06 发布日期:2006-02-28
  • 通讯作者: 汪焱钢

Synthesis and Biological Activity of N-(2-Carboxyl-1,3,4-thiadiazol- 5-yl)-N'-aroyl Thioureas and Aryloxyacetyl Thioureas

GONG Yin-Xiang1,3,WANG Zi-Yun2,ZHANG Zheng-Wen3
CHEN Chuan-Bing3,WANG Yan-Gang*,3   

  1. (1 College of Chemistry and Environment Engineering, Yangtze University, Jingzhou 434000)
    (2 Department of Chemistry, Zhoukou Normal University, Zhoukou 466000)
    (3 College of Chemistry, Central China Normal University, Wuhan 430079)
  • Received:2005-04-06 Revised:2005-09-06 Published:2006-02-28
  • Contact: WANG Yan-Gang

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被引次数

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为了寻找高活性的杂环农药, 用5-氨基-1,3,4-噻二唑-2-羧酸与芳酰基异硫氰酸酯及芳氧乙酰基异硫氰酸酯反应, 合成出18种新的芳酰基硫脲与芳氧乙酰基硫脲, 采用红外光谱、核磁共振氢谱和元素分析证明了其结构, 初步的生物活性测定试验表明, 部分目标化合物具有良好的植物生长调节活性, 其中2c, 2d, 3b和3g具有良好的生长素活性.

关键词: 芳氧乙酰基硫脲, 合成, 生物活性, 生长素, 芳酰基硫脲

In order to find high biological active pesticide, eighteen novel aroyl thioureas and aryloxyacetyl ones have been synthesized by the reaction of 5-amino-1,3,4-thiadiazol-2-carboxylic acid with aroyl isothiocyanates and aryloxyacetyl isothiocyanates, with their structure confirmed by IR, 1H NMR spectra and elemental analysis. The preliminary biological activity tests showed that some title compounds have good activity as plant growth regulator, and 2c, 2d, 3b and 3g have fine activity of auxin.

Key words: synthesis, auxin, biological activity, aryloxyacetyl thiourea, aroyl thiourea