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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (03): 387-390. 上一篇    下一篇

研究简报

3-(4-吡啶基)-4-(6-取代色酮-3-基-亚甲氨基)-5-芳氨基-1,2,4-三唑的合成

燕珂1，刘俊1，曹玲华*,1,2   

  1. (1新疆大学化学化工学院 乌鲁木齐 830046)
    (2南开大学元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2005-04-06 修回日期:2005-09-22 发布日期:2006-02-28
  • 通讯作者: 曹玲华

Synthesis of 3-(4-Pyridyl)-4-(6-substituted chro-mon-3-yl-methyleneamino)-5-arylamino-1,2,4-triazoles

YAN Ke1,LIU Jun1,CAO Ling-Hua*,1,2   

  1. (1 College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046)
    (2 State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071)
  • Received:2005-04-06 Revised:2005-09-22 Published:2006-02-28
  • Contact: CAO Ling-Hua

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1316

被引次数

21

N-芳基-N'-[(4-吡啶基)羰基]氨基硫脲用85%的水合肼环化, 得到3-(4-吡啶基)-4-氨基-5-芳氨基-1,2,4-三唑(2a～2c). 然后再与3-甲酰基色酮(3a～3d)反应, 制备得到了一系列新化合物: 3-(4-吡啶基)-4-(6-取代色酮-3-基亚甲氨基)-5-芳氨基-1,2,4-三唑(4a～4c, 5a～5c, 6a～6c, 7a～7c). 化合物的结构经元素分析, IR, 1H NMR和MS确证.

关键词: 3-甲酰基色酮, 1,2,4-三唑, 合成

N-Aryl-N'-[(4-pyridyl)-carbonyl]thiosemcarbazides were cyclized with hydrazine to afford the 3-(4-pyridyl)-4-amino-5-arylamino-1,2,4-triazoles (2a～2c). The triazoles 2a～2c reacted with 3-formyl- chromones 3a～3d giving a series of novel compounds 3-(4-pyridyl)-4-(6-substituted chromon-3-ylme- thyl-eneamino)-5-arylamino-1,2,4-triazoles (4a～4c, 5a～5c, 6a～6c, 7a～7c). The structures of the compounds were determined by IR, 1H NMR, MS spectra and elemental analyses.

Key words: 1,2,4-triazole, synthesis, 3-formylchromone